Tamura S, Kunimoto M, Tabata T, Yoshie O
Shionogi Institute for Medical Science, Osaka.
Jpn J Cancer Res. 1993 Mar;84(3):246-9. doi: 10.1111/j.1349-7006.1993.tb02863.x.
Types and certain genetic markers were studied for Epstein-Barr virus present in 10 specimens of nasopharyngeal carcinoma (NPC) from Japanese patients. The type 1 virus was predominant in our NPC specimens, as in the general Japanese population, and the type 2 virus was found only in one NPC specimen. The type C variant, which lacks the BamHI site between the BamHI-W1* and -I1* regions, appeared to be common among Japanese strains as in those in Southern China. The type f variant which has an extra BamHI site in the BamHI-F region and has been shown to be strongly associated with NPC in Southern China was found in only one NPC specimen. This virus strain was also the only type 2 virus among our specimens. The present study, therefore, does not show any specific association of the type f variant with NPC in Japan.
对来自日本患者的10份鼻咽癌（NPC）标本中存在的EB病毒的类型和某些基因标记进行了研究。与日本普通人群一样，1型病毒在我们的NPC标本中占主导地位，仅在一份NPC标本中发现了2型病毒。C型变体在BamHI-W1和-I1区域之间缺少BamHI位点，在中国南方的毒株中一样，在日本毒株中似乎也很常见。f型变体在BamHI-F区域有一个额外的BamHI位点，在中国南方已被证明与NPC密切相关，仅在一份NPC标本中发现。该病毒株也是我们标本中唯一的2型病毒。因此，本研究未显示f型变体与日本NPC之间存在任何特定关联。
