体内炎性巨噬细胞成熟过程中从白细胞介素1β（IL-1β）向IL-1α产生的转变。
Transition from interleukin 1 beta (IL-1 beta) to IL-1 alpha production during maturation of inflammatory macrophages in vivo.
作者信息
Beuscher H U, Rausch U P, Otterness I G, Röllinghoff M
机构信息
Institute of Clinical Microbiology, University of Erlangen-Nürnberg, Germany.
出版信息
J Exp Med. 1992 Jun 1;175(6):1793-7. doi: 10.1084/jem.175.6.1793.
Abstract
In situ production of interleukin 1 alpha (IL-1 alpha) and IL-1 beta was investigated in Peyer's patches (PP) of mice undergoing an acute bacterial infection with Yersinia enterocolitica O8. Synthesis of IL-1 beta, as determined by immunohistochemistry, was found primarily in monocytes migrating into the inflamed PP. In comparison, synthesis of IL-1 alpha was temporarily delayed by at least 24 h and was only found in mature macrophages, which did not produce detectable levels of IL-1 beta. This indicates a transition from IL-1 beta to IL-1 alpha production during maturation of monocytes into inflammatory macrophages, and further emphasizes a dichotomy between IL-1 alpha and IL-1 beta.
摘要
研究了感染小肠结肠炎耶尔森菌O8的小鼠派尔集合淋巴结（PP）中白细胞介素1α（IL-1α）和IL-1β的原位产生情况。通过免疫组织化学测定，发现IL-1β的合成主要发生在迁移至发炎PP的单核细胞中。相比之下，IL-1α的合成暂时延迟至少24小时，且仅在成熟巨噬细胞中发现，而这些成熟巨噬细胞不产生可检测水平的IL-1β。这表明在单核细胞成熟为炎性巨噬细胞的过程中，IL-1β的产生向IL-1α的产生转变，进一步强调了IL-1α和IL-1β之间的差异。
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