Hanna G L, Yuwiler A, Cantwell D P
Department of Psychiatry and Biobehavioral Sciences, School of Medicine, University of California, Los Angeles.
Biol Psychiatry. 1991 Apr 15;29(8):738-44. doi: 10.1016/0006-3223(91)90193-p.
Whole blood serotonin (5-HT) concentration was assessed in 16 children and adolescents with severe obsessive-compulsive disorder (OCD) and in 14 normal adolescent controls. There was no difference in blood 5-HT content between the OCD patients and the normal controls. However, the OCD patients with a family history of OCD had significantly higher blood 5-HT levels than did either the OCD patients without a family history of OCD or the normal controls. Blood 5-HT content was not associated with a history of major depressive disorder or chronic tic disorder. These preliminary results suggest that studies of serotonergic functioning in OCD may need to control for family history of OCD and that blood 5-HT may be a useful biochemical measure in family-genetic studies of OCD.
对16名患有重度强迫症（OCD）的儿童和青少年以及14名正常青少年对照者进行了全血血清素（5-羟色胺，5-HT）浓度评估。强迫症患者与正常对照者的血液5-HT含量没有差异。然而，有强迫症家族史的强迫症患者的血液5-HT水平显著高于没有强迫症家族史的强迫症患者或正常对照者。血液5-HT含量与重度抑郁症或慢性抽动障碍病史无关。这些初步结果表明，强迫症中血清素功能的研究可能需要控制强迫症家族史，并且血液5-HT可能是强迫症家族遗传研究中的一种有用的生化指标。
