Lien T C, Wang J H
Respiratory Therapy Department, Veterans General Hospital-Taipei.
Zhonghua Yi Xue Za Zhi (Taipei). 1992 May;49(5):348-53.
A patient with an artificial airway in place, pulmonary aspiration is a serious complication. A prospective study was conducted to investigate the incidence of pulmonary aspiration in patients with all kinds of modern artificial airways with high-volume low-pressure cuffs. In ICU and NSCU (neurosurgery care unit), 40 patients with a tracheostomy or endotracheal tube were included. Before study, cuff pressure was checked and remained at 25 cmH2 O if possible. Then, 0.2 ml of 1% methylene blue was applied on the tongue of each patient every 4 hours. Routine tube care was performed including frequent suction at least once an hour. Any evidence of the blue dye-marker obtained on suctioning was considered positive. The duration of study was 24 hours. Among these 40 patients, the procedure was performed in 50 episodes because some of the patients were evaluated with different kinds of artificial airways. Thirty episodes were evaluated with endotracheal tube, including 7 oral and 23 nasotracheal tubes. No episode of aspiration could be found (0/30). With tracheostomy tubes, 5 of 20 episodes showed positive result (5/20). The difference of incidence between these 2 groups was statistically significant (p less than 0.01). Some possible contributing factors were evaluated between positive and negative episodes, including age, sex, respiration rate, different brands of tracheostomy tubes, modes of ventilation, PEEP level, cuff pressure, nasogastric tubes, coma scale, posture, and ratio of tube and tracheal diameters in tracheostomy group.(ABSTRACT TRUNCATED AT 250 WORDS)
对于有人工气道的患者,肺误吸是一种严重的并发症。进行了一项前瞻性研究,以调查使用各种带大容量低压套囊的现代人工气道的患者中肺误吸的发生率。在重症监护病房(ICU)和神经外科监护病房(NSCU),纳入了40例接受气管切开术或气管插管的患者。研究前,检查套囊压力,若可能,使其保持在25 cmH₂O。然后,每4小时给每位患者的舌部涂抹0.2 ml 1%的亚甲蓝。进行常规的管道护理,包括至少每小时频繁吸痰一次。吸痰时获得的任何蓝色染料标记物的证据都被视为阳性。研究持续时间为24小时。在这40例患者中,该操作共进行了50次,因为有些患者使用了不同类型的人工气道进行评估。对30次气管插管进行了评估,包括7次口插管和23次鼻插管,未发现误吸情况(0/30)。对于气管切开管,20次中有5次显示阳性结果(5/20)。这两组之间的发生率差异具有统计学意义(p小于0.01)。对阳性和阴性病例之间的一些可能影响因素进行了评估,包括年龄、性别、呼吸频率、不同品牌的气管切开管、通气模式、呼气末正压水平、套囊压力、鼻胃管、昏迷评分、体位以及气管切开组中导管与气管直径的比例。(摘要截短于250字)