13型人乳头瘤病毒与1型倭黑猩猩乳头瘤病毒：基因组结构比较

Human papillomavirus type 13 and pygmy chimpanzee papillomavirus type 1: comparison of the genome organizations.

作者信息

Van Ranst M, Fuse A, Fiten P, Beuken E, Pfister H, Burk R D, Opdenakker G

机构信息

Laboratory of Molecular Medicine, Rega Institute, University of Leuven, Belgium.

出版信息

Virology. 1992 Oct;190(2):587-96. doi: 10.1016/0042-6822(92)90896-w.

DOI:10.1016/0042-6822(92)90896-w

PMID:1325697

Abstract

Human papillomavirus type 13(HPV-13) is associated with oral focal epithelial hyperplasia (FEH) in humans. A recent epidemic of a FEH-like disease in a pygmy chimpanzee (Pan paniscus) colony allowed us to clone a novel papillomavirus genome. To assess the homology between HPV-13 and the pygmy chimpanzee papillomavirus type 1 (PCPV-1), the complete nucleotide sequences of both FEH-related viruses were determined. In both viruses, all eight major open reading frames were located on one strand and the genomic organization was similar to that of other mucosal papillomaviruses. The genomes of PCPV-1 and HPV-13 showed extensive overall sequence homology (85%). They could be classified, using phylogenetic analysis, together with HPV types 6, 11, 43, and 44 in a group associated with benign orogenital lesions. These data indicate that two phylogenetically related papillomaviruses can elicit similar pathology in different primate host species, reflecting viral genomic similarities.

摘要

人乳头瘤病毒13型（HPV - 13）与人类口腔灶性上皮增生（FEH）相关。最近，在一个倭黑猩猩（Pan paniscus）群体中爆发了一种类似FEH的疾病，这使我们能够克隆出一种新型乳头瘤病毒基因组。为了评估HPV - 13与倭黑猩猩乳头瘤病毒1型（PCPV - 1）之间的同源性，我们测定了这两种与FEH相关病毒的完整核苷酸序列。在这两种病毒中，所有八个主要开放阅读框都位于一条链上，并且基因组结构与其他黏膜乳头瘤病毒相似。PCPV - 1和HPV - 13的基因组显示出广泛的总体序列同源性（85%）。通过系统发育分析，它们可以与6型、11型、43型和44型HPV归为一组，该组与良性口生殖器病变相关。这些数据表明，两种系统发育相关的乳头瘤病毒可以在不同的灵长类宿主物种中引发相似的病理变化，这反映了病毒基因组的相似性。