M 型不可分型 A 群链球菌序列类型的鉴定
Identification of sequence types among the M-nontypeable group A streptococci.
作者信息
Relf W A, Martin D R, Sriprakash K S
机构信息
Menzies School of Health Research, Casuarina, Australia.
出版信息
J Clin Microbiol. 1992 Dec;30(12):3190-4. doi: 10.1128/jcm.30.12.3190-3194.1992.
Abstract
Streptococcal diseases, namely, acute glomerulonephritis and acute rheumatic fever, are common features in the aboriginal population of the Northern Territory of Australia. We examined the group A streptococcal M types identified during various surveys conducted since 1987. Streptococci were predominantly isolated from skin infections. A high proportion of the isolates could not be serotyped by conventional means and were designated M nontypeable (MNT). M-specific DNA sequences from the MNT isolates were examined, and sequence types were proposed for the classification of MNTs. This allowed a more precise estimate of the M types present in a population study.
摘要
链球菌疾病，即急性肾小球肾炎和急性风湿热，是澳大利亚北领地原住民的常见病症。我们研究了自1987年以来在各项调查中鉴定出的A组链球菌M型。链球菌主要从皮肤感染中分离出来。很大一部分分离株无法通过传统方法进行血清分型，被指定为M非型（MNT）。对MNT分离株的M特异性DNA序列进行了检测，并提出了序列类型用于MNT的分类。这使得在人群研究中能够更精确地估计存在的M型。
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