Wyatt L S, Frenkel N
Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.
J Virol. 1992 May;66(5):3206-9. doi: 10.1128/JVI.66.5.3206-3209.1992.
We report the frequent isolation of human herpesvirus 7 from the saliva of healthy adults. Virus isolates recovered from different individuals exhibited minimal restriction enzyme polymorphism, which was mostly confined to heterogeneous (het) sequences in the genome. DNAs of isolates recovered from the same individual over a period of several months showed the same characteristic het fragments, indicating the stability of the het sequences upon virus replication and shedding in vivo. In contrast to the results of previous reports, human herpesvirus 6, the causative agent of roseola infantum, could not be isolated from the saliva specimens, raising questions regarding oral transmission of human herpesvirus 6 and human herpesvirus 7 to young children.
我们报告了从健康成年人唾液中频繁分离出人类疱疹病毒7。从不同个体分离出的病毒株显示出最小的限制性内切酶多态性，这主要局限于基因组中的异质（het）序列。在几个月的时间里从同一个体分离出的病毒株DNA显示出相同的特征性het片段，表明het序列在病毒体内复制和排出时具有稳定性。与先前报告的结果相反，幼儿急疹的病原体人类疱疹病毒6无法从唾液标本中分离出来，这引发了关于人类疱疹病毒6和人类疱疹病毒7向幼儿口腔传播的问题。
