Thomas D B, Jimenez L M, McTiernan A, Rosenblatt K, Stalsberg H, Stemhagen A, Thompson W D, Curnen M G, Satariano W, Austin D F
Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA 98104.
Am J Epidemiol. 1992 Apr 1;135(7):734-48. doi: 10.1093/oxfordjournals.aje.a116360.
Cases included in a population-based case-control study of breast cancer in men were recruited from 10 geographic areas of the United States from 1983 to 1986. Controls, matched to cases on age and geographic area, were selected by random digit dialing for men under age 65 years and from Health Care Financing Administration files for older men. Results are based on responses from 227 cases and 300 controls to questions asked in a standardized personal interview. An increased risk of breast cancer was most strongly associated with undescended testes and was also related to orchiectomy, orchitis, testicular injury, late puberty, and infertility; and a decreasing trend in risk was observed with an increasing number of children. Relative risk estimates were also elevated in relation to a history of high blood cholesterol, rapid weight gain, benign breast conditions, and possibly obesity. These findings suggest that breast cancer in men develops in response to androgen deficiency associated with testicular dysfunction and under conditions associated with excess estrogen. Risk was also found to be elevated in men with a history of amphetamine use, diabetes, and cigar smoking and reduced in men with prior head trauma.
1983年至1986年期间，在美国10个地理区域招募了基于人群的男性乳腺癌病例对照研究中的病例。对照根据年龄和地理区域与病例匹配，65岁以下男性通过随机数字拨号选择，65岁及以上男性从医疗保健财务管理局档案中选取。结果基于227例病例和300例对照在标准化个人访谈中对问题的回答。男性乳腺癌风险增加与隐睾症关联最为密切，也与睾丸切除术、睾丸炎、睾丸损伤、青春期延迟和不育有关；随着子女数量增加，风险呈下降趋势。与高胆固醇血症病史、体重快速增加、乳腺良性疾病以及可能的肥胖症相关的相对风险估计值也有所升高。这些发现表明，男性乳腺癌是在与睾丸功能障碍相关的雄激素缺乏以及与雌激素过多相关的条件下发生的。有使用苯丙胺、糖尿病和吸烟史的男性风险也有所升高，有头部外伤史的男性风险降低。
