Fowkes F G, Leng G C, Donnan P T, Deary I J, Riemersma R A, Housley E
Wolfson Unit for Prevention of Peripheral Vascular Diseases, Department of Public Health Sciences, University of Edinburgh, UK.
Lancet. 1992 Oct 24;340(8826):995-8. doi: 10.1016/0140-6736(92)93009-c.
A higher than expected number of violent deaths and suicides in coronary prevention trials has provoked interest in the possibility that low serum cholesterol concentrations are associated in the general population with personality characteristics predisposing to aggressive and suicidal behaviour. We have investigated this possibility in the Edinburgh Artery Study. We measured serum lipid concentrations in blood samples taken from fasting subjects and assessed personality characteristics on the Bedford Foulds Personality Deviance Scales in a random sample of 1592 men and women aged 55-74 years, selected from age-sex registers of ten general practices in Edinburgh. Serum cholesterol concentration was not significantly associated with aggression in men, but it was associated in multivariate analysis (though not univariate analysis) with denigratory attitudes towards others among women. However, serum triglyceride concentration was related, especially in men, to hostile acts (r = 0.13, p < 0.001) and domineering attitude (r = 0.12, p < 0.001) independently of age, total and HDL cholesterol, cigarette smoking, and alcohol consumption. Subjects taking part in prevention trials have higher triglyceride concentrations than the general population and the relation between serum triglyceride concentration and aggression merits further investigation.
在冠心病预防试验中，暴力死亡和自杀的人数高于预期，这引发了人们对于低血清胆固醇浓度在普通人群中是否与易导致攻击和自杀行为的人格特征相关的兴趣。我们在爱丁堡动脉研究中对这种可能性进行了调查。我们测量了空腹受试者血样中的血清脂质浓度，并在从爱丁堡十家普通诊所的年龄性别登记册中随机抽取的1592名年龄在55至74岁之间的男性和女性样本中，根据贝德福德·福尔兹人格偏差量表评估了人格特征。血清胆固醇浓度在男性中与攻击性无显著关联，但在多变量分析中（单变量分析中未显示）与女性对他人的诋毁态度相关。然而，血清甘油三酯浓度与敌意行为（r = 0.13，p < 0.001）和专横态度（r = 0.12，p < 0.001）相关，尤其在男性中，且独立于年龄、总胆固醇和高密度脂蛋白胆固醇、吸烟及饮酒情况。参与预防试验的受试者甘油三酯浓度高于普通人群，血清甘油三酯浓度与攻击性之间的关系值得进一步研究。
