Holm P S, Krupp G
Institute for General Microbiology, Christian-Albrechts-Universität, Kiel, FRG.
Nucleic Acids Res. 1992 Feb 11;20(3):421-3. doi: 10.1093/nar/20.3.421.
As the result of an unusual RNase P specificity, some special, mature tRNAs have acceptor stems with eight instead of the common seven base pairs. The data from numerous studies suggest that some features in the tRNA domain of pre-tRNAs are important for this behaviour. Here, we show that only five base pairs in the acceptor stem of bacterial histidine tRNAs are required to obtain the changed cleavage site in an unrelated eukaryotic serine tRNA.
由于核糖核酸酶P具有不寻常的特异性，一些特殊的成熟转运RNA（tRNA）的受体茎有八个碱基对，而非常见的七个碱基对。大量研究的数据表明，前体tRNA的tRNA结构域中的某些特征对此行为很重要。在这里，我们表明，细菌组氨酸tRNA受体茎中只需五个碱基对，就能在不相关的真核丝氨酸tRNA中获得改变的切割位点。
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