幽门螺杆菌中120千道尔顿蛋白的表达及细胞毒性
Expression of 120 kilodalton protein and cytotoxicity in Helicobacter pylori.
作者信息
Crabtree J E, Figura N, Taylor J D, Bugnoli M, Armellini D, Tompkins D S
机构信息
Department of Medicine, St James's University Hospital, Leeds.
出版信息
J Clin Pathol. 1992 Aug;45(8):733-4. doi: 10.1136/jcp.45.8.733.
Abstract
Antral biopsy culture supernatants from 14 subjects with chronic gastritis, known to have IgA antibodies to the 120 kilodalton protein, showed positive recognition of this antigen in western blots against a cytotoxin positive strain of Helicobacter pylori but gave negative reactions with two cytotoxin negative strains. Control immunoblots with culture supernatants from 13 non-responders to the protein were all negative. This indicates a direct association between expression of the 120 kilodalton protein in H pylori strains and cytotoxicity.
摘要
14名患有慢性胃炎且已知对120千道尔顿蛋白有IgA抗体的受试者的胃窦活检培养上清液，在针对细胞毒素阳性幽门螺杆菌菌株的蛋白质印迹中显示对该抗原的阳性识别，但与两种细胞毒素阴性菌株产生阴性反应。13名对该蛋白无反应者的培养上清液对照免疫印迹均为阴性。这表明幽门螺杆菌菌株中120千道尔顿蛋白的表达与细胞毒性之间存在直接关联。
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