Sallaz M, Jourdan F
Physiologie neurosensorielle, CNRS, Université Claude Bernard/Lyon, Villeurbanne, France.
Neuroreport. 1992 Oct;3(10):833-6. doi: 10.1097/00001756-199210000-00003.
The olfactory bulb of adult male rats stimulated with propionic acid vapours displays a characteristic focus of high metabolic activity in the dorso-medial glomeruli, as revealed by the 2-deoxyglucose (2DG) method. Injection of the dopaminergic agonist apomorphine (1.5 mg kg-1) prior to odour stimulation completely abolishes this selective pattern of glomerular activation, while the metabolic activity of other bulbar areas is not significantly altered. This effect is abolished by a previous injection of the dopamine antagonist haloperidol (0.1 mg kg-1). These observations emphasize the probable involvement of dopamine and dopamine receptors in the bulbar processing of olfactory information.
用丙酸蒸汽刺激成年雄性大鼠的嗅球时，如采用2-脱氧葡萄糖（2DG）法所示，在背内侧肾小球中会显示出一个具有高代谢活性的特征性焦点。在气味刺激前注射多巴胺能激动剂阿扑吗啡（1.5毫克/千克）可完全消除这种肾小球激活的选择性模式，而其他嗅球区域的代谢活性则没有明显改变。预先注射多巴胺拮抗剂氟哌啶醇（0.1毫克/千克）可消除这种效应。这些观察结果强调了多巴胺和多巴胺受体可能参与了嗅球对嗅觉信息的处理。
