Sehgal V N, Bhattacharya S N, Shah Y, Rao Y N, Gupta C K
Department of Dermatology and Venereology, Maulana Azad Medical College, New Delhi.
Clin Exp Dermatol. 1992 Jan;17(1):20-3. doi: 10.1111/j.1365-2230.1992.tb02526.x.
Twenty-five patients with type 1 (lepra) and type 2 (E.N.L.) leprosy reactions were studied for lymphocyte adenosine deaminase activity (L-ADA), during and after treatment of the reactions, using a standard technique, in order to establish its pattern and if possible, its value in assessing the course of reactions. The results were compared with those from 30 control subjects, comprising 10 normal healthy adults, 10 patients with borderline tuberculoid (BT) leprosy, four patients with borderline lepromatous (BL) leprosy and six patients with lepromatous (LL) leprosy. The level of L-ADA in the leprosy controls was higher than that of normal healthy subjects. The L-ADA values in patients with different types of reactions were about 10-fold higher than those obtained from leprosy controls, emphasizing a possible role in assessing reactions in leprosy. However, there was no significant variation in L-ADA levels, either between the various leprosy controls or reaction groups, before and after treatment.
对25例1型（麻风反应）和2型（结节性红斑型麻风反应）麻风反应患者，在反应治疗期间及之后，采用标准技术研究淋巴细胞腺苷脱氨酶活性（L-ADA），以确定其模式，并在可能的情况下确定其在评估反应进程中的价值。将结果与30名对照受试者的结果进行比较，30名对照受试者包括10名正常健康成年人、10例界线类偏结核样型（BT）麻风患者、4例界线类偏瘤型（BL）麻风患者和6例瘤型（LL）麻风患者。麻风对照者的L-ADA水平高于正常健康受试者。不同类型反应患者的L-ADA值比麻风对照者获得的值高约10倍，强调了其在评估麻风反应中的可能作用。然而，在治疗前后，不同麻风对照者或反应组之间的L-ADA水平均无显著差异。
