苏联四项对照现场试验中伤寒疫苗的研究结果
RESULTS OF THE STUDY OF TYPHOID VACCINES IN FOUR CONTROLLED FIELD TRIALS IN THE USSR.
作者信息
HEJFEC L B
出版信息
Bull World Health Organ. 1965;32(1):1-14.
In field trials of typhoid vaccine in the USSR, a comparison was made of the effectiveness of chemical, heat-killed, and alcoholized vaccines. All of them conferred protection if administered in sufficient dosage, and variations in effectiveness could usually be traced to size of dosage. The heat-killed vaccine, however, appeared to be significantly more effective than the others. The immunological history of a vaccinated person apparently had no essential influence on the effectiveness of a vaccine, and the data indicated that two doses of the vaccine conferred no greater protection than one.
在苏联进行的伤寒疫苗现场试验中，对化学疫苗、热灭活疫苗和酒精处理疫苗的有效性进行了比较。如果给予足够的剂量，所有这些疫苗都能提供保护，有效性的差异通常可以追溯到剂量大小。然而，热灭活疫苗似乎比其他疫苗明显更有效。接种者的免疫史显然对疫苗的有效性没有实质性影响，数据表明，两剂疫苗提供的保护并不比一剂更大。
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