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化疗对食管腺癌超微结构的影响。

Effects of chemotherapy on ultrastructure of oesophageal adenocarcinoma.

作者信息

Darnton S J, Antonakopoulos G N, Newman J, Matthews H R

机构信息

Oesophageal Research Laboratory, East Birmingham Hospital.

出版信息

J Clin Pathol. 1992 Nov;45(11):979-83. doi: 10.1136/jcp.45.11.979.

DOI:10.1136/jcp.45.11.979
PMID:1452793
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC495028/
Abstract

AIMS

To compare and contrast the ultrastructural appearance of resected oesophageal adenocarcinomas treated with preoperative chemotherapy with that of non-treated resected controls; and to determine the usefulness of this method in the assessment of the effectiveness of the chemotherapeutic regimen.

METHODS

Ten resected oesophageal adenocarcinomas treated with preoperative chemotherapy--mitomycin-C, ifosfamide, and cisplatin (MIC)--were examined by transmission electron microscopy and their appearance compared with that of 13 concurrent untreated resected oesophageal adenocarcinomas.

RESULTS

The treated adenocarcinomas showed cytotoxic damage although complete tumour eradication was not achieved. In all 10 treated cases a variable proportion of the neoplastic cells showed unusual degenerative and necrotic changes not seen in untreated cases. In the most affected carcinomas the stroma contained increased numbers of inflammatory cells.

CONCLUSIONS

This ultrastructural method is useful for the assessment of the in vivo effect of MIC.

摘要

目的

比较经术前化疗的切除食管腺癌与未治疗的切除对照样本的超微结构表现；并确定该方法在评估化疗方案有效性方面的实用性。

方法

对10例经术前化疗（丝裂霉素-C、异环磷酰胺和顺铂，即MIC方案）治疗的切除食管腺癌进行透射电子显微镜检查，并将其表现与13例同期未治疗的切除食管腺癌进行比较。

结果

尽管未实现肿瘤完全根除，但经治疗的腺癌显示出细胞毒性损伤。在所有10例经治疗的病例中，不同比例的肿瘤细胞呈现出未治疗病例中未见的异常退行性和坏死性变化。在受影响最严重的癌组织中，基质中炎症细胞数量增加。

结论

这种超微结构方法有助于评估MIC方案的体内效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bad/495028/59d0c1d23334/jclinpath00425-0045-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bad/495028/bd7bc19e1839/jclinpath00425-0042-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bad/495028/704428097989/jclinpath00425-0042-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bad/495028/e273b0b41543/jclinpath00425-0043-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bad/495028/c3a34fc313b5/jclinpath00425-0043-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bad/495028/264f2d5cc893/jclinpath00425-0044-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bad/495028/b57a2f7eb247/jclinpath00425-0044-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bad/495028/98d638dd4b71/jclinpath00425-0045-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bad/495028/59d0c1d23334/jclinpath00425-0045-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bad/495028/bd7bc19e1839/jclinpath00425-0042-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bad/495028/704428097989/jclinpath00425-0042-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bad/495028/e273b0b41543/jclinpath00425-0043-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bad/495028/c3a34fc313b5/jclinpath00425-0043-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bad/495028/264f2d5cc893/jclinpath00425-0044-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bad/495028/b57a2f7eb247/jclinpath00425-0044-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bad/495028/98d638dd4b71/jclinpath00425-0045-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bad/495028/59d0c1d23334/jclinpath00425-0045-b.jpg

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本文引用的文献

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Cell structure and function and response to chemotherapy in tumors heterotransplanted into the subrenal capsule of mice and rats.移植到小鼠和大鼠肾被膜下的肿瘤的细胞结构、功能及对化疗的反应。
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The ultrastructure of transitional cell carcinomas of the human urinary bladder treated with ethoglucid or mitomycin.用环氧氯丙烷或丝裂霉素治疗的人膀胱癌移行细胞癌的超微结构
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Assessment of the response to chemotherapy in oesophageal cancer.
食管癌化疗反应的评估
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The ultrastructure of oesophageal carcinomas: multidirectional differentiation. A transmission electron microscopic study of 43 cases.食管癌的超微结构：多向分化。43例病例的透射电子显微镜研究。
J Pathol. 1992 Jun;167(2):193-8. doi: 10.1002/path.1711670206.
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The electron microscopy of normal human oesophageal epithelium.正常人类食管上皮的电子显微镜检查
Virchows Arch B Cell Pathol. 1978 Feb 14;26(4):345-58. doi: 10.1007/BF02889561.