Everaert K, Mahmoud A, Depuydt C, Maeyaert M, Comhaire F
Department of Urology, Ghent University Hospital, Ghent, Belgium.
Andrologia. 2003 Oct;35(5):325-30.
The aim of this article was to discuss by means of a review of the literature and own study material the multifactorial aetiology of male infertility, extrapolate this hypothesis to male accessory gland infection (MAGI) and relate it to chronic prostatitis and its treatment. Infertility is a multifactorial disease and diagnosis and therapy must be oriented as such. Although the relationship between prostatitis and infertility remains unclear, bacteria, viruses, leucocytes, reactive oxygen species, cytokines, obstruction and immunological abnormalities must be seen as cofactors in the development of infertility in patients with MAGI and prostatitis. Infection, trauma, allergy, neurogenic damage, chemical or mechanical factors can lead to a long-lasting inflammation of the prostate or pelvic organs even after eradication of the aetiological agent, and is potentially related to infertility through cytokines. In relation to treatment of infertility, antibiotics play a role in bacterial prostatitis whereas in abacterial prostatitis other treatments like antioxidants, sacral nerve stimulation and anti-inflammatory treatment are worth to be studied in the future.
本文旨在通过文献综述和自身研究资料，探讨男性不育的多因素病因，将该假说外推至男性附属腺感染（MAGI），并将其与慢性前列腺炎及其治疗相关联。不育是一种多因素疾病，诊断和治疗必须以此为导向。虽然前列腺炎与不育之间的关系仍不明确，但细菌、病毒、白细胞、活性氧、细胞因子、梗阻和免疫异常必须被视为患有MAGI和前列腺炎患者不育症发生发展的辅助因素。感染、创伤、过敏、神经源性损伤、化学或机械因素可导致前列腺或盆腔器官的长期炎症，即使在病因消除后也是如此，并且可能通过细胞因子与不育相关。关于不育症的治疗，抗生素在细菌性前列腺炎中发挥作用，而在非细菌性前列腺炎中，抗氧化剂、骶神经刺激和抗炎治疗等其他治疗方法未来值得研究。
