Hardt Philip D, Hauenschild Annette, Jaeger Clemens, Teichmann Joachim, Bretzel Reinhard G, Kloer Hans U
Third Medical Department and Policlinic, Giessen University Hospital, Giessen, Germany.
Dig Dis Sci. 2003 Sep;48(9):1688-92. doi: 10.1023/a:1025422423435.
Impaired exocrine pancreatic secretion has been frequently observed in diabetic patients by different methods, including direct function tests. However, the clinical importance remained unclear. In the present study, the fecal fat excretion in patients with type 1 or type 2 diabetes mellitus and exocrine dysfunction according to fecal elastase 1 concentrations <100 microg/g was investigated. Subjects with a history of gastrointestinal cancer, gastrointestinal surgery, alcohol abuse, or inflammatory diseases were excluded. In 101 patients the mean (+/- SD) fat excretion was 9.19 +/- 5.39 g. Only 41 patients (40.6%) had normal fat excretion <7 g/day. In 40 patients (39.6%), it was higher than 10 g/day, indicating relevant steatorrhea. The fat excretion did not correlate with diabetes type, duration, or clinical symptoms. This finding is of some clinical importance and might influence pathophysiological concepts and the management of diabetic patients.
通过不同方法，包括直接功能测试，在糖尿病患者中经常观察到胰腺外分泌功能受损。然而，其临床重要性仍不清楚。在本研究中，对1型或2型糖尿病且根据粪便弹性蛋白酶1浓度<100微克/克判断存在外分泌功能障碍的患者的粪便脂肪排泄情况进行了调查。排除有胃肠道癌症、胃肠道手术、酗酒或炎症性疾病史的受试者。101例患者的平均（±标准差）脂肪排泄量为9.19±5.39克。只有41例患者（40.6%）的脂肪排泄正常<7克/天。40例患者（39.6%）的脂肪排泄量高于10克/天，表明存在明显的脂肪泻。脂肪排泄与糖尿病类型、病程或临床症状无关。这一发现具有一定的临床重要性，可能会影响病理生理学概念和糖尿病患者的管理。
