Kountouras Jannis, Mylopoulos Nikolaos, Konstas Anastasios G P, Zavos Christos, Chatzopoulos Dimitrios, Boukla Anna
Graefes Arch Clin Exp Ophthalmol. 2003 Nov;241(11):884-90. doi: 10.1007/s00417-003-0779-5. Epub 2003 Oct 24.
A prospective, nonrandomized, comparative study was carried out to investigate the levels of anti- H. pylori-specific IgG antibodies in the aqueous humor and serum of patients with primary open-angle glaucoma (POAG) and patients with exfoliation glaucoma (XFG), and to compare them with those in age-matched cataract patients.
Aqueous humor was aspirated at the beginning of glaucoma surgery from 26 eyes of 26 patients with POAG, 27 eyes of 27 patients with XFG, and at the beginning of phakoemulsification cataract surgery from 31 eyes of 31 age-matched normotensive cataract patients. Serum samples were obtained the day before surgery from all patients. Anti- H. pylori IgG concentration in the aqueous humor and serum was measured by means of an enzyme-linked immunosorbent assay.
The mean concentration (+/- SE) of anti- H. pylori-specific IgG was significantly greater in the aqueous humor samples from patients with POAG (14.27+/-3.86 U/ml) and XFG (14.25+/-3.39 U/ml) than in those from age-matched control cataract patients (4.67+/-1.07 U/ml); ( P=0.006 and P=0.003, respectively). No difference was observed in the levels of H. pylori-specific IgG antibodies between POAG and XFG aqueous humor samples ( P=0.5). Similarly, the serum concentration of anti- H. pylori antibodies was significantly greater in patients with POAG (69.96+/-9.69 U/ml; P=0.013) and XFG (81.37+/-10.62 U/ml; P=0.002) than in the cataract controls (44.16+/-6.48 U/ml). The mean vertical cupping correlated significantly with the titer of anti- H. pylori-specific IgG in the aqueous humor in the POAG patients.
H. pylori-specific IgG antibody levels are significantly increased in the aqueous humor and serum of patients with POAG and XFG. Moreover, the titer of anti- H. pylori antibody in the aqueous humor might reflect the severity of glaucomatous damage in POAG patients. These findings support a role for H. pylori infection in the pathobiology of these two common glaucomas.
开展一项前瞻性、非随机对照研究，以调查原发性开角型青光眼（POAG）患者和剥脱性青光眼（XFG）患者房水和血清中抗幽门螺杆菌特异性IgG抗体水平，并与年龄匹配的白内障患者进行比较。
在青光眼手术开始时，采集26例POAG患者的26只眼、27例XFG患者的27只眼的房水；在超声乳化白内障手术开始时，采集31例年龄匹配的血压正常的白内障患者的31只眼的房水。所有患者均在手术前一天采集血清样本。采用酶联免疫吸附测定法检测房水和血清中抗幽门螺杆菌IgG浓度。
POAG患者（14.27±3.86 U/ml）和XFG患者（14.25±3.39 U/ml）房水样本中抗幽门螺杆菌特异性IgG的平均浓度（±标准误）显著高于年龄匹配的对照白内障患者（4.67±1.07 U/ml）；（分别为P = 0.006和P = 0.003）。POAG和XFG房水样本中幽门螺杆菌特异性IgG抗体水平无差异（P = 0.5）。同样，POAG患者（69.96±9.69 U/ml；P = 0.013）和XFG患者（81.37±10.62 U/ml；P = 0.002）血清中抗幽门螺杆菌抗体浓度显著高于白内障对照组（44.16±6.48 U/ml）。POAG患者平均垂直杯盘比与房水中抗幽门螺杆菌特异性IgG滴度显著相关。
POAG和XFG患者房水和血清中幽门螺杆菌特异性IgG抗体水平显著升高。此外，房水中抗幽门螺杆菌抗体滴度可能反映POAG患者青光眼损害的严重程度。这些发现支持幽门螺杆菌感染在这两种常见青光眼发病机制中的作用。
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