Venables P J, Shattles W, Pease C T, Ellis J E, Charles P J, Maini R N
Clinical Immunology Division, Kennedy Institute of Rheumatology, London, U.K.
Clin Exp Rheumatol. 1989 Mar-Apr;7(2):181-4.
We examined the diagnostic sensitivity and specificity of antibodies to Ro (SS-A) and La (SS-B) in Sjögren's syndrome (SS) by counterimmunoelectrophoresis and immunodiffusion. Anti-Ro was found in 56% and anti-La in 42% of patients with SS and in 38% and 6% respectively in SLE. Anti-La was rare (less than 1%) in other connective tissue diseases. As a more stringent test of diagnostic specificity, 88 patients whose sera contained anti-La and/or anti-Ro were carefully examined for evidence of Sjögren's syndrome. Of 35 patients whose sera contained anti-La, 29 (83%) fulfilled criteria for SS, and four out of 6 of the remainder showed some evidence of early disease. Of 53 patients with anti-Ro (without anti-La), only 42% had Sjögren's syndrome, 45% had SLE and 13% other connective tissue diseases. These data confirm that anti-La, but not anti-Ro, has a high diagnostic specificity for Sjögren's syndrome and merits inclusion as separate diagnostic criterion for the disease.
我们通过对流免疫电泳和免疫扩散法检测了抗Ro（SS - A）和抗La（SS - B）抗体在干燥综合征（SS）中的诊断敏感性和特异性。在SS患者中，56%检测到抗Ro，42%检测到抗La；在系统性红斑狼疮（SLE）患者中，抗Ro和抗La的检出率分别为38%和6%。抗La在其他结缔组织疾病中罕见（低于1%）。作为对诊断特异性的更严格检测，对88例血清中含有抗La和/或抗Ro的患者进行了仔细检查，以寻找干燥综合征的证据。在35例血清中含有抗La的患者中，29例（83%）符合SS标准，其余6例中有4例显示出早期疾病的一些证据。在53例抗Ro（无抗La）患者中，只有42%患有干燥综合征，45%患有SLE，13%患有其他结缔组织疾病。这些数据证实，抗La而非抗Ro对干燥综合征具有较高的诊断特异性，值得作为该疾病单独的诊断标准纳入。
