Skopouli F N, Andonopoulos A P, Moutsopoulos H M
Department of Internal Medicine, School of Medicine, University of Ioannina, Greece.
J Autoimmun. 1988 Aug;1(4):381-8. doi: 10.1016/0896-8411(88)90008-x.
The clinical and serologic findings in 25 patients with rheumatoid arthritis (RA) of more than 5 years' duration, who had antibodies to Ro(SSA) cellular antigen, were analyzed and compared with those in 50 anti-Ro(SSA) negative RA patients with similar disease duration. Ninety-six percent of the anti-Ro(SSA) positive patients were female, compared to 74% in the negative group. The majority of antibody positive patients had symmetric erosive synovitis, similar to that observed in the negative group. Extra-articular manifestations were similar in both groups, except for features of Sjögren's syndrome (keratoconjunctivitis sicca and positive labial salivary gland biopsy), which were significantly more common in patients with anti-Ro(SSA) antibodies. Anemia of chronic disease was also more common in these patients, as were rheumatoid factor (RF) and antinuclear antibodies (ANAs). No patient in either group had antibodies to ds-DNA or Sm and none developed clinical features suggestive of systemic lupus erythematosus (SLE). D-penicillamine, given in the majority of patients in both groups, produced adverse reactions in 72% of the anti-Ro(SSA) positive patients, but only in 27% of the negative ones. Thus, anti-Ro(SSA) antibodies seem to characterize a distinct group of RA patients who are almost exclusively female, express more activated B-cell function, have a high prevalence of Sjögren's features and commonly develop side effects to D-penicillamine.
对25例病程超过5年且具有抗Ro(SSA)细胞抗原抗体的类风湿关节炎（RA）患者的临床和血清学检查结果进行了分析，并与50例病程相似但抗Ro(SSA)阴性的RA患者进行了比较。抗Ro(SSA)阳性患者中96%为女性，而阴性组这一比例为74%。大多数抗体阳性患者有对称性侵蚀性滑膜炎，与阴性组所见相似。两组的关节外表现相似，但干燥综合征（角结膜干燥症和唇唾液腺活检阳性）的特征在抗Ro(SSA)抗体阳性患者中明显更为常见。这些患者中慢性病性贫血也更常见，类风湿因子（RF）和抗核抗体（ANA）也是如此。两组患者中均无抗双链DNA或Sm抗体，也均未出现提示系统性红斑狼疮（SLE）的临床特征。两组大多数患者均使用了青霉胺，72%的抗Ro(SSA)阳性患者出现了不良反应，而阴性组只有27%出现不良反应。因此，抗Ro(SSA)抗体似乎可作为一组独特的RA患者的特征，这些患者几乎均为女性，B细胞功能更活跃，干燥综合征特征的患病率高，且使用青霉胺时常见副作用。
