Boyom Fabrice Fekam, Ngouana Vincent, Zollo Paul Henri Amvam, Menut Chantal, Bessiere Jean Marie, Gut Jiri, Rosenthal Philip J
Department of Biochemistry, Faculty of Science, University of Yaoundé I, Cameroon.
Phytochemistry. 2003 Dec;64(7):1269-75. doi: 10.1016/j.phytochem.2003.08.004.
In a search for new plant-derived biologically active compounds against malaria parasites, five essential oils extracted from the Cameroonian plants Xylopia phloiodora, Pachypodanthium confine, Antidesma laciniatum, Xylopia aethiopica, and Hexalobus crispiflorus were evaluated in regard to their anti-plasmodial activity against the W2 strain of Plasmodium falciparum. The oils were obtained from the plants with 0.12, 0.13, 0.18, 0.6 and 0.1% yields (relatively to dried material weight) respectively. Analysis by gas chromatography and mass spectrometry identified mainly terpenoids, among which alpha-copaene, gamma-cadinene, delta-cadinene, alpha-cadinol, spathulenol and caryophyllene oxide were most commonly found. The five oils were active against Plasmodium falciparum in culture. The most effective was the oil of Hexalobus crispiflorus, with an IC50 of 2 microg/ml.
为了寻找新的源自植物的抗疟生物活性化合物，对从喀麦隆植物多花肉豆蔻、围延包豆、撕裂五月茶、埃塞俄比亚肉豆蔻和皱花风车子中提取的五种精油针对恶性疟原虫W2株的抗疟活性进行了评估。这些精油分别从植物中以0.12%、0.13%、0.18%、0.6%和0.1%的产率（相对于干燥材料重量）获得。通过气相色谱和质谱分析主要鉴定出萜类化合物，其中最常见的是α-可巴烯、γ-杜松烯、δ-杜松烯、α-杜松醇、匙叶桉油烯醇和氧化石竹烯。这五种精油在培养物中对恶性疟原虫具有活性。最有效的是皱花风车子的精油，IC50为2微克/毫升。
