Kuribayashi Takashi, Shimada Tokihiro, Matsumoto Mariko, Kawato Katsuhito, Honjyo Toshio, Fukuyama Masafumi, Yamamoto Yutaka, Yamamoto Shizuo
Laboratory of Immunology, College of Environmental and Health Sciences, Azabu University, Sagamihara, Kanagawa, Japan.
Exp Anim. 2003 Oct;52(5):387-90. doi: 10.1538/expanim.52.387.
Serum C-reactive protein (CRP) concentrations in healthy beagle dogs of various ages and in pregnant beagles were measured by enzyme-linked immunosorbent assay (ELISA). Serum CRP concentrations were 1.5-16.0 microg/ml (mean 7.9 +/- 3.4 microg/ml) in male, and 1.8-18.9 microg/ml (mean 8.3 +/- 4.0 microg/ml) in female dogs. No significant sex-related differences were observed in the values. Further, there were no significant age-related differences either. Serum CRP concentrations increased during pregnancy. The concentration of serum CRP in pregnant dogs peaked at 70.2-90.4 microg/ml (mean 77.5 +/- 7.1 microg/ml) 30 or 45 days after ovulation, demonstrating two characteristic features of CRP concentration change in pregnant dogs.
采用酶联免疫吸附测定法（ELISA）测定了不同年龄的健康比格犬和怀孕比格犬血清C反应蛋白（CRP）浓度。雄性犬血清CRP浓度为1.5 - 16.0微克/毫升（平均7.9±3.4微克/毫升），雌性犬为1.8 - 18.9微克/毫升（平均8.3±4.0微克/毫升）。未观察到与性别相关的显著差异。此外，也没有与年龄相关的显著差异。怀孕过程中血清CRP浓度升高。怀孕犬血清CRP浓度在排卵后30或45天达到峰值，为70.2 - 90.4微克/毫升（平均77.5±7.1微克/毫升），这显示了怀孕犬CRP浓度变化的两个特征。
