Abu el Asrar A M, Maimone D, Morse P H, Gregory S, Reder A T
Department of Ophthalmology, Mansoura University Hospital, Egypt.
Am J Ophthalmol. 1992 Dec 15;114(6):731-6. doi: 10.1016/s0002-9394(14)74052-8.
Sixteen vitreous and paired serum samples from 13 patients with proliferative diabetic retinopathy, vitreous samples from seven cadaveric control subjects, and aqueous humor samples from 15 normal control subjects were assayed for the cytokines interleukin-1, tumor necrosis factor-alpha, interleukin-6, and interferon-gamma. Interleukin-6 was detected in 15 of 16 vitreous samples (94%) from diabetic patients, but it was not detected in any of the aqueous humor samples. Vitreous interleukin-6 levels positively correlated with ocular disease activity. Interleukin-1 was detected in seven of 16 vitreous samples (44%) and in four of ten aqueous humor samples (40%), whereas tumor necrosis factor-alpha and interferon-gamma were never detected in vitreous or aqueous fluid. Serum samples from diabetic patients and control subjects contained comparable low levels of interleukin-6. Interleukin-1, tumor necrosis factor-alpha, and interferon-gamma were not found in any of the sera. Because interleukin-6 can function as B-cell differentiation factor, this cytokine may have a role in immunoglobulin deposition in the ocular tissues and in the immunopathologic characteristics of proliferative retinopathy.
对13例增殖性糖尿病视网膜病变患者的16份玻璃体样本及配对血清样本、7例尸体对照受试者的玻璃体样本和15例正常对照受试者的房水样本进行了细胞因子白细胞介素-1、肿瘤坏死因子-α、白细胞介素-6和干扰素-γ的检测。在糖尿病患者的16份玻璃体样本中有15份（94%）检测到白细胞介素-6，但在任何房水样本中均未检测到。玻璃体白细胞介素-6水平与眼部疾病活动呈正相关。在16份玻璃体样本中有7份（44%）检测到白细胞介素-1，在10份房水样本中有4份（40%）检测到白细胞介素-1，而在玻璃体或房水中从未检测到肿瘤坏死因子-α和干扰素-γ。糖尿病患者和对照受试者的血清样本中白细胞介素-6水平相当低。在任何血清中均未发现白细胞介素-1、肿瘤坏死因子-α和干扰素-γ。由于白细胞介素-6可作为B细胞分化因子发挥作用，这种细胞因子可能在眼部组织中的免疫球蛋白沉积以及增殖性视网膜病变的免疫病理特征中起作用。
