Fang F C, Libby S J, Buchmeier N A, Loewen P C, Switala J, Harwood J, Guiney D G
Department of Medicine, University of California, San Diego 92103.
Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):11978-82. doi: 10.1073/pnas.89.24.11978.
Nutrient limitation is a critical signal in Salmonella virulence gene regulation. The katF (rpoS) gene mediates the expression of the Salmonella spv plasmid virulence genes during bacterial starvation. A katF Salmonella mutant has increased susceptibility to nutrient deprivation, oxidative stress, acid stress, and DNA damage, conditions which are relevant to the intraphagosomal environment of host macrophages. Moreover, the katF mutant has significantly reduced virulence in mice. katF encodes an alternative sigma factor of RNA polymerase which coordinately regulates Salmonella virulence.
营养限制是沙门氏菌毒力基因调控中的一个关键信号。katF（rpoS）基因在细菌饥饿期间介导沙门氏菌spv质粒毒力基因的表达。katF沙门氏菌突变体对营养剥夺、氧化应激、酸应激和DNA损伤的敏感性增加，这些情况与宿主巨噬细胞的吞噬体环境相关。此外，katF突变体在小鼠中的毒力显著降低。katF编码RNA聚合酶的一种替代σ因子，它协调调节沙门氏菌的毒力。
