Zachariae R, Zachariae H, Blomqvist K, Davidsson S, Molin L, Mørk C, Sigurgeirsson B
Psychooncology Research Unit, Aarhus University Hospital, Denmark.
J Eur Acad Dermatol Venereol. 2004 Jan;18(1):27-36. doi: 10.1111/j.1468-3083.2004.00721.x.
The purpose of the study was to investigate the perceived influence of stress on psoriasis onset and disease severity in a large sample of psoriatics and to compare stress reactors and non-reactors with respect to psoriasis-related stress, disease severity, family history of psoriasis and sociodemographic factors.
PATIENTS/METHODS: A total of 5795 members of the Nordic psoriasis associations and 702 patients recruited from Nordic dermatologists or university clinics were asked whether their first outbreak of psoriasis occurred during times of worry and stress. They were also asked to rate the degree to which their psoriasis was influenced by stress and to complete the Psoriasis Life Stress Index, the Psoriasis Disability Index and a number of additional questions concerning sociodemographic factors.
Seventy-one per cent of the members and 66% of the patients reported that their psoriasis was exacerbated by stress, and 35% in both groups reported that the onset of their psoriasis occurred during a time of worry and stress. Stress reactors, scoring above the median on stress reactivity, reported greater disease severity, psoriasis-related stress and impairment of disease-related quality of life. They also reported more frequent use of tobacco, tranquillizers and antidepressants. More women than men were stress reactors, and stress reactors were more likely to have a family history of psoriasis.
Our findings confirm and extend the results of previous studies and indicate that a subgroup of psoriatics may be more psychologically reactive to their disease and its influence on everyday life. Whether this group is also physiologically more reactive to psychosocial stress remains to be investigated.
本研究旨在调查大量银屑病患者中压力对银屑病发病及疾病严重程度的感知影响,并比较压力反应者和非压力反应者在银屑病相关压力、疾病严重程度、银屑病家族史及社会人口学因素方面的差异。
患者/方法:共有5795名北欧银屑病协会成员以及从北欧皮肤科医生或大学诊所招募的702名患者被问及他们首次银屑病发作是否发生在焦虑和压力时期。他们还被要求评估压力对其银屑病的影响程度,并完成银屑病生活压力指数、银屑病残疾指数以及一些关于社会人口学因素的附加问题。
71%的协会成员和66%的患者报告称压力会加重他们的银屑病,两组中均有35%的人报告其银屑病发作发生在焦虑和压力时期。压力反应者在压力反应性方面得分高于中位数,他们报告的疾病严重程度更高、银屑病相关压力更大以及疾病相关生活质量受损更严重。他们还报告更频繁地使用烟草、镇静剂和抗抑郁药。女性压力反应者多于男性,且压力反应者更可能有银屑病家族史。
我们的研究结果证实并扩展了先前研究的结果,表明一部分银屑病患者可能在心理上对其疾病及其对日常生活的影响更具反应性。这一组在生理上是否也对心理社会压力更具反应性仍有待研究。