Zachariae Hugh, Zachariae Robert, Blomqvist Kirsti, Davidsson Steingrimur, Molin Lars, Mørk Cato, Sigurgeirsson Bardur
Department of Dermatology, Aarhus University Hospital, Denmark.
Acta Derm Venereol. 2002;82(2):108-13. doi: 10.1080/00015550252948130.
Quality of life measures are widely used in dermatology as well as in rheumatology, but there are no large studies taking arthritis into consideration when studying quality of life in psoriasis. The aim of this study was to investigate psoriasis-related quality of life in a large sample of members of the psoriasis associations from the Nordic countries including an arthritis-related evaluation. The prevalence of reported arthritis within the groups was also estimated. An Arthritis Disability Index suitable for parallel use together with Finlay's Psoriasis Disability Index was constructed. A total of 5,795 members and 702 patients seen by Nordic dermatologists rated the severity of their disease and completed the Psoriasis Disability Index formula and a Psoriasis Life Stress Inventory, and if arthritis had been diagnosed, the Arthritis Disability Index formula. Approximately 30% of all psoriatic patients, irrespective of group, received a diagnosis of arthritis either by their dermatologist or a rheumatologist. Members previously hospitalized for their disease had a higher frequency of arthritis (41%) than those without a history of hospitalization (23%). The highest prevalence of arthritis was found in Norway (33.8%). Members with arthritis exhibited greater impairment of psoriasis-related quality of life, longer disease duration, and greater self-reported disease severity for psoriasis. Important predictors for impairment of arthritis-related quality of life were pain, number of affected joints, and restriction of joint mobility. These data show, that the prevalence of arthritis in psoriasis may be significantly higher than the previously accepted average of 7%. The results demonstrate that when studying quality of life in psoriasis, arthritis and arthralgia are important independent factors to be included in the evaluation.
生活质量测量方法在皮肤科和风湿病学中都有广泛应用,但在研究银屑病的生活质量时,尚无大型研究将关节炎纳入考虑范围。本研究的目的是在包括关节炎相关评估在内的北欧国家银屑病协会的大量成员样本中,调查与银屑病相关的生活质量。还估计了各群体中报告的关节炎患病率。构建了一种适合与芬利银屑病残疾指数并行使用的关节炎残疾指数。共有5795名成员和702名由北欧皮肤科医生诊治的患者对其疾病严重程度进行了评分,并完成了银屑病残疾指数公式和银屑病生活压力量表,如果已诊断出关节炎,则完成关节炎残疾指数公式。所有银屑病患者中,无论所属群体如何,约30%的患者被皮肤科医生或风湿病医生诊断患有关节炎。曾因该病住院的成员患关节炎的频率(41%)高于无住院史的成员(23%)。关节炎患病率最高的是挪威(33.8%)。患有关节炎的成员在与银屑病相关的生活质量方面受损更大,病程更长,且自我报告的银屑病疾病严重程度更高。与关节炎相关的生活质量受损的重要预测因素是疼痛、受累关节数量和关节活动受限。这些数据表明,银屑病患者中关节炎的患病率可能显著高于先前公认的7%的平均水平。结果表明,在研究银屑病的生活质量时,关节炎和关节痛是评估中应纳入的重要独立因素。