Van Wymelbeke V, Béridot-Thérond M-E, de La Guéronnière V, Fantino M
Equipe Nutrition et Métabolisme Humain et CREABIO, Université de Bourgogne, Dijon, France.
Eur J Clin Nutr. 2004 Jan;58(1):154-61. doi: 10.1038/sj.ejcn.1601762.
To investigate the influence of ingestion of beverages with sucrose or with intense sweeteners on food intake (FI) and on hunger ratings in before and after a month of daily consumption of beverages.
Experimental study.
Department of Physiology, University Hospital, Dijon, France.
In all, 12 men and 12 women, aged 20-25 y.
Four beverages contained either sucrose (E+:100 g/l, 1672 kJ) or intense sweeteners (E-: null energy content) and were flavoured with either orange (O) or raspberry (R). FI was measured in the lab during two 2-consecutive-day periods, carried out on 2 successive weeks (session 1). The subjects drank 2 l of either E+ or E- beverages on the first day of both weekly periods, according to a balanced randomised design. E+ was paired with O for 50% of subjects and with R for the other 50%. Subjects were then habituated over a 4-week period to both beverages, consuming 1 l of E+ beverage on odd days and 1 l of E- drink on even days. After this period, the measurements of session 1 were repeated (session 2, weeks 7-8). Finally, FI was measured for two more 2-day periods (weeks 9-10) after the association between flavour and energy content was reversed (session 3).
The E- drinks were less palatable than the E+ drinks. Besides, we observed that FI was not reduced in response to a liquid extra caloric load and there was no change in hunger ratings after the beverages in any of the sessions.
Ingestion of caloric beverages induced a positive energy balance and the continuous exposure phase to these beverages over 1 month did not improve FI adaptation in response to the extra energy provided by the beverages.
研究每日饮用含蔗糖饮料或含高强度甜味剂饮料对食物摄入量（FI）以及饥饿评分的影响，观察期为一个月，分别测量饮用前后的情况。
实验研究。
法国第戎大学医院生理学系。
共24名受试者，年龄在20 - 25岁之间，其中男性12名，女性12名。
四种饮料，一种含有蔗糖（E +：100 g/L，1672 kJ），另一种含有高强度甜味剂（E -：零能量），并分别用橙子味（O）或树莓味（R）调味。在连续两周内进行两个连续两天的实验期，在实验室测量食物摄入量（FI）（第1阶段）。根据平衡随机设计，受试者在每周实验期的第一天饮用2升E +或E -饮料。50%的受试者饮用搭配橙子味的E +饮料，另外50%饮用搭配树莓味的E +饮料。之后，受试者在4周内习惯饮用这两种饮料，奇数天饮用1升E +饮料，偶数天饮用1升E -饮料。此阶段过后，重复第1阶段的测量（第2阶段，第7 - 8周）。最后，在口味与能量含量的搭配颠倒后，再进行两个为期两天的食物摄入量测量（第9 - 10周，第3阶段）。
E -饮料不如E +饮料可口。此外，我们观察到，额外的液体热量负荷并未使食物摄入量减少，且在任何一个实验阶段，饮用饮料后饥饿评分均无变化。
摄入含热量饮料会导致正能量平衡，且连续1个月饮用这些饮料并未改善机体对饮料所提供额外能量的食物摄入量适应性。
