Folsom Aaron R, Demissie Zewditu, Harnack Lisa
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA.
Nutr Cancer. 2003;46(2):119-24. doi: 10.1207/S15327914NC4602_03.
Although specific foods or nutrients have not been linked consistently with risk of endometrial cancer, obesity and diabetes are associated with increased risk. These conditions may be influenced by the glycemic index or load of the usual diet. We therefore examined the association of glycemic index and load measured at baseline using a food frequency questionnaire in a cohort of 23335 postmenopausal women. Over 15 yr of follow-up, we identified 415 incident endometrial cancers. The average glycemic index was not associated with endometrial cancer occurrence. After adjustment for other risk factors, the average glycemic load was positively but weakly associated, with a relative risk of 1.24 (95% CI = 0.90-1.72) for the highest versus lowest quintile of glycemic load (P for trend = 0.08). This relative risk was 1.46 (95% CI = 1.02-2.08; P for trend = 0.02) among nondiabetic women, but the trend was in the opposite direction among diabetic women. Our study indicates that a higher dietary glycemic load may be a risk factor for endometrial cancer incidence in nondiabetic women.
尽管特定食物或营养素与子宫内膜癌风险之间并未始终存在关联，但肥胖和糖尿病与风险增加相关。这些情况可能受日常饮食的血糖指数或血糖负荷影响。因此，我们在一个由23335名绝经后女性组成的队列中，使用食物频率问卷对基线时测量的血糖指数和血糖负荷之间的关联进行了研究。在超过15年的随访中，我们确定了415例新发子宫内膜癌病例。平均血糖指数与子宫内膜癌的发生无关。在对其他风险因素进行调整后，平均血糖负荷呈正相关但关联较弱，血糖负荷最高五分位数与最低五分位数相比，相对风险为1.24（95%置信区间=0.90-1.72）（趋势P值=0.08）。在非糖尿病女性中，这一相对风险为1.46（95%置信区间=1.02-2.08；趋势P值=0.02），但在糖尿病女性中趋势相反。我们的研究表明，较高的饮食血糖负荷可能是非糖尿病女性子宫内膜癌发病的一个风险因素。
