Hasselbalch S G, Oberg G, Sørensen S A, Andersen A R, Waldemar G, Schmidt J F, Fenger K, Paulson O B
Department of Neurology, Rigshospitalet, University State Hospital, Copenhagen, Denmark.
J Neurol Neurosurg Psychiatry. 1992 Nov;55(11):1018-23. doi: 10.1136/jnnp.55.11.1018.
Regional cerebral blood flow (rCBF) was studied in 18 patients with Huntington's disease (HD) and 19 age- and sex-matched controls with high resolution single photon emission computerised tomography (SPECT), using Tc-99m-HMPAO. Significant reductions in tracer uptake were found in the caudate and lentiform nuclei (20 and 8%) and in the cerebral cortex, especially in the frontal and parietal areas (11-13%). No significant reductions were found in the thalamus, mesial temporal cortex, and occipital cortex. Fourteen patients had neuropsychological testing. Relationship between rCBF and cognitive function was tested by regression analysis. A linear relationship was found between test scores of Wisconsin Card Sorting Test, Picture Arrangement Test and blood flow in the caudate nucleus. Other tests of cognitive function (Block Design Test, Face and Word Recognition Test, Street Fragmented Pictures Test, and Similarities Test) correlated better with flow in the cortical regions believed to be involved in solving those particular tests. These findings indicate, that blood flow is reduced in both cortical and subcortical structures in symptomatic HD, and that both reductions in cortical and subcortical blood flow may be related to cognitive function in HD.
采用锝-99m-六甲基丙二胺肟（Tc-99m-HMPAO），利用高分辨率单光子发射计算机断层扫描（SPECT）对18例亨廷顿病（HD）患者及19名年龄和性别匹配的对照者的局部脑血流量（rCBF）进行了研究。结果发现，尾状核和豆状核的示踪剂摄取显著减少（分别为20%和8%），大脑皮质尤其是额叶和顶叶区域也显著减少（11%-13%）。丘脑、颞叶内侧皮质和枕叶皮质未发现显著减少。14例患者进行了神经心理学测试。通过回归分析检验rCBF与认知功能之间的关系。发现威斯康星卡片分类测验、图片排列测验的测试分数与尾状核血流量之间存在线性关系。其他认知功能测试（积木图案测验、面部和单词识别测验、街道碎图测验和相似性测验）与据信参与解决那些特定测试的皮质区域血流量的相关性更好。这些发现表明，有症状的HD患者皮质和皮质下结构的血流量均减少，且皮质和皮质下血流量的减少均可能与HD的认知功能有关。
