使用臭氧治疗根龋的临床疗效逆转：双盲、随机、对照18个月试验

Clinical reversal of root caries using ozone, double-blind, randomised, controlled 18-month trial.

作者信息

Holmes J

机构信息

UKSmiles Dental Practice, Wokingham, Berkshire, UK.

出版信息

Gerodontology. 2003 Dec;20(2):106-14. doi: 10.1111/j.1741-2358.2003.00106.x.

DOI:10.1111/j.1741-2358.2003.00106.x

PMID:14697022

Abstract

OBJECTIVE

To assess the effect of an ozone delivery system, combined with the daily use of a remineralising patient kit, on the clinical severity of non-cavitated leathery primary root carious lesions (PRCL's), in an older population group.

DESIGN

A total of 89 subjects, (age range 60-82, mean +/- SD, 70.8 +/- 6 years), each with two leathery PRCL's, were recruited. The two lesions in each subject were randomly assigned for treatment with ozone or air, in a double-blind design, in a general dental practice. Subjects were recalled at three, six, 12 and 18 months. Lesions were clinically recorded at each visit as soft, leathery or hard, scored with a validated root caries severity index.

RESULTS

There were no observed adverse events. After three months, in the ozone-treated group, 61 PRCL's (69%) had become hard and none had deteriorated, whilst in the control group, four PRCL's (4%) had become worse (p<0.01). At the six-month recall, in the ozone group, seven PRCL's (8%) remained leathery, the remaining 82 (92%) PRCL's had become hard, whilst in the control group, 10 PRCL's had become worse (11%) and one had become hard (p<0.01). At 12 and 18 months, 87 Subjects attended. In the ozone group at 12 months, two PRCL's remained leathery, compared to 85 (98%) that had hardened, whilst in the control group 21 (24%) of the PRCL's had progressed from leathery to soft, i.e. became worse, 65 PRCL's (75%) were still leathery, and one remained hard (p<0.01). At 18 months, 87 (100%) of ozone-treated PRCL's had arrested, whilst in the control group, 32 lesions (37%) of the PRCL's had worsened from leathery to soft (p<0.01), 54 (62%) PRCL's remained leathery and only one of the control PRCL's had reversed (p<0.01).

CONCLUSIONS

Leathery non-cavitated primary root caries can be arrested non-operatively with ozone and remineralising products. This treatment regime is an effective alternative to conventional "drilling and filling".

摘要

目的

评估臭氧输送系统结合日常使用再矿化患者套装，对老年人群非龋洞性皮革状原发性根龋损害（PRCL）临床严重程度的影响。

设计

共招募89名受试者（年龄范围60 - 82岁，平均±标准差，70.8±6岁），每人有两个皮革状PRCL。在一家普通牙科诊所，采用双盲设计，将每位受试者的两个损害随机分配用臭氧或空气进行治疗。在3、6、12和18个月时对受试者进行复诊。每次复诊时对损害进行临床记录，分为软、皮革状或硬，并使用经过验证的根龋严重程度指数进行评分。

结果

未观察到不良事件。三个月后，在臭氧治疗组中，61个PRCL（69%）变硬且无恶化，而在对照组中，4个PRCL（4%）恶化（p<0.01）。在六个月复诊时，在臭氧组中，7个PRCL（8%）仍为皮革状，其余82个（92%）PRCL变硬，而在对照组中，10个PRCL恶化（11%），1个变硬（p<0.01）。在12个月和18个月时，87名受试者前来复诊。在臭氧组12个月时，2个PRCL仍为皮革状，相比之下85个（98%）已变硬，而在对照组中，21个（24%）PRCL从皮革状进展为软，即恶化，65个PRCL（75%）仍为皮革状，1个仍为硬（p<0.01）。在18个月时，87个（100%）接受臭氧治疗的PRCL已停止发展，而在对照组中，32个（37%）PRCL从皮革状恶化为软（p<0.01），54个（62%）PRCL仍为皮革状，对照组中只有1个PRCL好转（p<0.01）。