英国人类牛分枝杆菌病的分子流行病学
Molecular epidemiology of disease due to Mycobacterium bovis in humans in the United Kingdom.
作者信息
Gibson Andrea L, Hewinson Glyn, Goodchild Tony, Watt Brian, Story Alistair, Inwald Jacqueline, Drobniewski Francis A
机构信息
Department of Microbiology, Guy's, King's and St Thomas' School of Medicine, King's College Hospital (Dulwich), East Dulwich Grove, London, SE22 8QF, United Kingdom.
出版信息
J Clin Microbiol. 2004 Jan;42(1):431-4. doi: 10.1128/JCM.42.1.431-434.2004.
Abstract
Mycobacterium bovis is the causative agent of bovine tuberculosis, with a wide host range. Fifty human M. bovis isolates were typed using spoligotyping and variable number tandem repeats (VNTR). Fifteen of these spoligotypes have not yet been recorded in cattle. The predominant spoligotype in humans and cattle was subdivided by VNTR.
摘要
牛分枝杆菌是牛结核病的病原体，宿主范围广泛。使用间隔寡核苷酸分型（spoligotyping）和可变数目串联重复序列（VNTR）对50株人源牛分枝杆菌分离株进行分型。其中15种间隔寡核苷酸分型在牛中尚未有记录。通过VNTR对人和牛中占主导地位的间隔寡核苷酸分型进行了细分。
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