Rosenbloom S Trent, Awad Joseph, Speroff Ted, Elkin Peter L, Rothman Russell, Spickard Anderson, Peterson Josh, Bauer Brent A, Wahner-Roedler Dietland L, Lee Mark, Gregg William M, Johnson Kevin B, Jirjis Jim, Erlbaum Mark S, Carter John S, Lincoln Michael J, Brown Steven H
Vanderbilt University, USA.
AMIA Annu Symp Proc. 2003;2003:569-78.
The National Drug File Reference Terminology contains a novel reference hierarchy to describe physiologic effects (PE) of drugs. The PE reference hierarchy contains 1697 concepts arranged into two broad categories; organ specific and generalized systemic effects. This investigation evaluated the appropriateness of the PE concepts for classifying a random selection of commonly prescribed medications. Ten physician reviewers classified the physiologic effects of ten drugs and rated the accuracy of the selected term. Inter reviewer agreement, overall confidence, and concept frequencies were assessed and were correlated with the complexity of the drug's known physiologic effects. In general, agreement between reviewers was fair to moderate (kappa 0.08-0.49). The physiologic effects modeled became more disperse with drugs having and inducing multiple physiologic processes. Complete modeling of all physiologic effects was limited by reviewers focusing on different physiologic processes. The reviewers were generally comfortable with the accuracy of the concepts selected. Overall, the PE reference hierarchy was useful for physician reviewers classifying the physiologic effects of drugs. Ongoing evolution of the PE reference hierarchy as it evolves should take into account the experiences of our reviewers.
国家药品档案参考术语包含一种新颖的参考层次结构，用于描述药物的生理效应（PE）。PE参考层次结构包含1697个概念，分为两大类：器官特异性效应和全身性效应。本研究评估了PE概念对随机选择的常用处方药进行分类的适用性。十位医生评审员对十种药物的生理效应进行了分类，并对所选术语的准确性进行了评分。评估了评审员之间的一致性、总体信心和概念频率，并将其与药物已知生理效应的复杂性相关联。总体而言，评审员之间的一致性为中等（kappa值为0.08 - 0.49）。随着药物具有和诱导多种生理过程，所模拟的生理效应变得更加分散。由于评审员关注不同的生理过程，所有生理效应的完整建模受到限制。评审员通常对所选概念的准确性感到满意。总体而言，PE参考层次结构对医生评审员对药物的生理效应进行分类很有用。随着PE参考层次结构的不断发展，其持续演变应考虑我们评审员的经验。
