[适应性伺服通气：对潮式呼吸及生活质量的影响]

[Adaptive servoventilation: effect on Cheyne-Stokes-Respiration and on quality of life].

作者信息

Töpfer V, El-Sebai M, Wessendorf T E, Moraidis I, Teschler H

机构信息

Ruhrlandklinik, Das Lungenzentrum, Abteilung Pneumologie/Schlaf- und Beatmungsmedizin, Essen.

出版信息

Pneumologie. 2004 Jan;58(1):28-32. doi: 10.1055/s-2003-812438.

DOI:10.1055/s-2003-812438

PMID:14732897

Abstract

BACKGROUND

Adaptive servo-ventilation (ASV) (AutoSetCS, ResMed) is a novel non-invasive ventilation modality for the treatment of Cheyne-Stokes-Respiration (CSR) in patients with heart failure. This study aimed to investigate the effect of ASV on sleep disordered breathing (SDB), afternoon nap duration, urine voidings, and quality of life.

METHODS

11 patients with CSR due to heart failure (EF < 40 %) were treated with ASV for a period of 6 weeks. Apnea-Hypopnoe-Index (AHI), Arousalindex (AI), duration of afternoon nap, number of voidings, and heart specific quality of life were assessed before and at the end of the treatment period.

RESULTS

The average usage time of ASV was 5.8 +/- 2.1/h per day. With ASV the AHI was reduced from 48.2 +/- 11.6 to 6.4 +/- 8.3/h (p < 0.001) and the AI from 33.9 +/- 12.5 to 18.4 +/- 9.3 /h (p < 0.05). The afternoon nap duration was significantly less (1.4 +/- 0.6 vs. 0.7 +/- 0.4 hours per day; p = 0.004) as was the number of nocturnal voidings (2.9 +/- 0.7 vs. 1.1 +/- 0.3 per night; p = 0.007). There was a significant improvement in heart specific quality of life as measured with the Minnesota Living with heart failure questionnaire (43.5 +/- 21.1 vs. 27.6 +/- 15.7 (p = 0.02).

CONCLUSION

ASV is well tolerated and improves SDB and quality of life of patients with heart failure with CSR.

摘要

背景

适应性伺服通气（ASV）（AutoSetCS，瑞思迈公司）是一种用于治疗心力衰竭患者潮式呼吸（CSR）的新型无创通气方式。本研究旨在探讨ASV对睡眠呼吸紊乱（SDB）、午睡时长、夜尿次数及生活质量的影响。

方法

11例因心力衰竭导致CSR的患者（左心室射血分数<40%）接受了为期6周的ASV治疗。在治疗期开始前及结束时评估呼吸暂停低通气指数（AHI）、觉醒指数（AI）、午睡时长、夜尿次数及心脏特异性生活质量。

结果

ASV的平均使用时间为每天5.8±2.1小时。使用ASV后，AHI从48.2±11.6次/小时降至6.4±8.3次/小时（p<0.001），AI从33.9±12.5次/小时降至18.4±9.3次/小时（p<0.05）。午睡时长显著缩短（每天1.4±0.6小时对0.7±0.4小时；p=0.004），夜间排尿次数也显著减少（每晚2.9±0.7次对1.1±0.3次；p=0.007）。根据明尼苏达心力衰竭生活问卷评估，心脏特异性生活质量有显著改善（43.5±21.1对27.6±15.7（p=0.02））。