Young A L, Tang W W T, Lam D S C
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, People's Republic of China.
Br J Ophthalmol. 2004 Feb;88(2):193-5. doi: 10.1136/bjo.2003.021816.
Pseudoexfoliation syndrome (PXS) is regarded as rare in people of Chinese ethnicity but the prevalence of this condition is not known. This epidemiology study was conducted to assess the prevalence of PXS in cataract patients and to report the clinical features present.
Prospective descriptive study conducted in the period from March 1999 to May 2001 in ophthalmology departments in cluster hospitals serving a population of about 1.2 million. 500 consecutive patients aged 60 or above attending the general ophthalmic clinics with a presumed diagnosis of cataract were recruited. A detailed examination including biomicroscopy, intraocular measurement, and gonioscopy were performed on all patients. All positive PXS cases were documented photographically.
500 patients were examined. They ranged from the ages of 60 to 91 years old, with a male to female ratio of 1:2. 40% suffered from hypertension while 24% were known diabetics. Only two positive cases (0.4%) of PXS were identified in the study population. 18% of all eyes were found to have narrow angles (defined as grade 0 to 2 by Shaffer grading). Nuclear sclerosis was the single most common type of lens opacity.
PXS is a rare condition in Chinese people. A prevalence rate of 0.4% in patients aged 60 or above was identified in this hospital based epidemiology study. To the best of our knowledge, this was the first study conducted in a Chinese population to examine the prevalence of PXS.
假性剥脱综合征（PXS）在中国人群中被认为较为罕见，但其患病率尚不清楚。本流行病学研究旨在评估白内障患者中PXS的患病率，并报告所呈现的临床特征。
1999年3月至2001年5月在服务于约120万人口的多家综合医院眼科进行前瞻性描述性研究。招募了500例年龄在60岁及以上、初诊为白内障的普通眼科门诊连续患者。对所有患者进行了包括生物显微镜检查、眼内测量和前房角镜检查在内的详细检查。所有PXS阳性病例均进行了拍照记录。
共检查了500例患者。年龄范围为60至91岁，男女比例为1:2。40%患有高血压，24%为已知糖尿病患者。在研究人群中仅发现2例PXS阳性病例（0.4%）。所有眼中18%被发现有窄房角（根据Shaffer分级定义为0至2级）。核硬化是最常见的晶状体混浊类型。
PXS在中国人群中是一种罕见疾病。在本基于医院的流行病学研究中，60岁及以上患者的患病率为0.4%。据我们所知，这是首次在中国人群中进行的关于PXS患病率的研究。
