Vogt K, Hermann J, Blume U, Gollnick H, Hahn H, Haustein U F, Orfanos C E
Institute of Medical Microbiology, Free University of Berlin, Germany.
Eur J Clin Microbiol Infect Dis. 1992 Oct;11(10):943-5. doi: 10.1007/BF01962381.
The antibacterial activity of the topical quinolone OPC-7251 against bacteria commonly found in acne vulgaris was tested in vitro by an agar dilution method. The MIC50 was 0.25 mg/l for Propionibacterium acnes, 0.125 mg/l for Propionibacterium granulosum, 0.03 mg/l for Staphylococcus aureus and 0.06 mg/l for coagulase-negative staphylococci. Compared with seven other antibiotics tested (ciprofloxacin, penicillin, erythromycin, tetracycline, clindamycin, fusidic acid and gentamicin), OPC-7251 had potent activity against both propionibacteria and staphylococci and the lowest incidence of resistant strains.
采用琼脂稀释法在体外测试了外用喹诺酮OPC - 7251对寻常痤疮常见细菌的抗菌活性。痤疮丙酸杆菌的MIC50为0.25mg/l，颗粒丙酸杆菌为0.125mg/l，金黄色葡萄球菌为0.03mg/l，凝固酶阴性葡萄球菌为0.06mg/l。与其他七种测试抗生素（环丙沙星、青霉素、红霉素、四环素、克林霉素、夫西地酸和庆大霉素）相比，OPC - 7251对丙酸杆菌和葡萄球菌均具有强效活性，且耐药菌株的发生率最低。
