Bittar R S, Cruz O L, Lorenzi M C, Marone S A, Miniti A
Ear, Nose, and Throat Department, University of São Paulo, School of Medicine, São Paulo, Brazil.
Int Tinnitus J. 2001;7(1):41-5.
The aim of this study was to analyze the morphological cochlear changes and auditory function observed after the administration of estrogen or progesterone or both. Sixty-two guinea pigs were divided into four groups that received estrogen (group 1), progesterone (group 2), estrogen and progesterone (group 3), and saline solution (controls, group 4), respectively. The auditory evaluation consisted of brainstem evoked response audiometry, performed before and after drug administration. Structural analysis was based on histological hematoxylin and eosin staining preparations. Our results showed changes in latency and amplitude of waves in the study groups that received estrogen or progesterone. The main histological changes observed were inflammatory infiltrate and vacuolization of the stria vascularis. Our results suggest that both estrogen and progesterone lead to morphological and physiological lesions of the cochlea, the degree of the observed lesions depending not only on the presence of these hormones but also on the proportion between them.
本研究的目的是分析给予雌激素或孕激素或两者后观察到的耳蜗形态变化和听觉功能。62只豚鼠被分为四组，分别接受雌激素（第1组）、孕激素（第2组）、雌激素和孕激素（第3组）以及生理盐水（对照组，第4组）。听觉评估包括在给药前后进行的脑干诱发反应测听。结构分析基于组织学苏木精和伊红染色制剂。我们的结果显示，接受雌激素或孕激素的研究组中波的潜伏期和振幅发生了变化。观察到的主要组织学变化是血管纹的炎性浸润和空泡化。我们的结果表明，雌激素和孕激素都会导致耳蜗的形态和生理损伤，观察到的损伤程度不仅取决于这些激素的存在，还取决于它们之间的比例。
