分枝杆菌纯化蛋白衍生物刺激先天性免疫：与英国青少年相比，马拉维人表现出更强的肿瘤坏死因子α、白细胞介素-1β（IL-1β）和IL-10反应。
Mycobacterial purified protein derivatives stimulate innate immunity: Malawians show enhanced tumor necrosis factor alpha, interleukin-1beta (IL-1beta), and IL-10 responses compared to those of adolescents in the United Kingdom.
作者信息
Weir Rosemary E, Black Gillian F, Dockrell Hazel M, Floyd Sian, Fine Paul E M, Chaguluka Steven D, Stenson Sally, King Elizabeth, Nazareth Bernadette, Warndorff David K, Ngwira Bagrey, Crampin Amelia C, Mwaungulu Lorren, Sichali Lifted, Jarman Elizabeth, Donovan Linda, Blackwell Jenefer M
机构信息
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.
出版信息
Infect Immun. 2004 Mar;72(3):1807-11. doi: 10.1128/IAI.72.3.1807-1811.2004.
Abstract
To investigate the role of innate immunity in variable efficacy of Mycobacterium bovis BCG vaccination in Malawi and the United Kingdom, we examined 24-h tumor necrosis factor alpha, interleukin-1beta (IL-1beta), and IL-10 responses to mycobacterial purified protein derivatives (PPDs). The rank order in stimulatory potency for different PPDs was the same for all three cytokines. Before vaccination Malawians made higher pro- and anti-inflammatory responses than did United Kingdom subjects. Fewer than 5% of United Kingdom subjects made IL-10 in response to any PPD, compared to 19 to 57% responders among Malawians. Priming for regulatory IL-10 may contribute to the smaller increase in gamma interferon responses in Malawians compared to United Kingdom subjects following BCG vaccination.
摘要
为研究天然免疫在马拉维和英国卡介苗接种效果差异中的作用，我们检测了对分枝杆菌纯化蛋白衍生物（PPD）的24小时肿瘤坏死因子α、白细胞介素-1β（IL-1β）和IL-10反应。三种细胞因子对不同PPD的刺激效力排序相同。接种疫苗前，马拉维人产生的促炎和抗炎反应高于英国受试者。英国受试者中对任何PPD产生IL-10反应的不到5%，而马拉维人的反应者比例为19%至57%。与英国受试者相比，马拉维人接种卡介苗后γ干扰素反应增幅较小，可能与调节性IL-10的启动有关。
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