Levine R, Robbins J A, Maser A
Department of Neurology, William S. Middleton Memorial Veterans Administration Hospital, Madison, Wisconsin 53705.
Dysphagia. 1992;7(3):142-7. doi: 10.1007/BF02493446.
Cranial magnetic resonance imaging (MRI) has revealed patchy periventricular white matter lesions or "unidentified bright objects" (UBOs) in otherwise neurologically intact individuals. Quantitative videofluoroscopic swallowing evaluations and cranial MRI examinations were studied in 49 neurologically normal volunteers (ages 43 to 79 years). Total swallowing duration (TSD) and its subcomponents of oral transit duration (OTD), stage transition duration (STD), and pharyngeal response duration were measured for liquid and semisolid swallows. MRIs were graded from 0, or no UBOs, to 3, or multiple and confluent lesions. The effect of the presence of UBOs on swallowing durational measures and risk factors was analyzed with age differences accounted for statistically (ANCOVA). TSD and OTD for semisolids were significantly differentiated by MRI score (P less than 0.009 and P less than 0.047, respectively). That is, a demonstrable effect was found for an increased number of UBOs on duration of oropharyngeal swallowing in normal individuals.
头颅磁共振成像（MRI）显示，在其他神经系统正常的个体中存在斑片状脑室周围白质病变或“不明高信号灶”（UBOs）。对49名神经系统正常的志愿者（年龄43至79岁）进行了定量视频荧光吞咽评估和头颅MRI检查。测量了液体和半固体吞咽的总吞咽持续时间（TSD）及其口腔通过时间（OTD）、阶段转换时间（STD）和咽部反应时间等子成分。MRI的分级从0（即无UBOs）到3（即多个融合性病变）。在统计学上考虑年龄差异的情况下（协方差分析），分析了UBOs的存在对吞咽持续时间测量值和危险因素的影响。半固体的TSD和OTD根据MRI评分有显著差异（分别为P<0.009和P<0.047）。也就是说，在正常个体中发现UBOs数量增加对口咽吞咽持续时间有明显影响。
