Dimitrov Dimiter S
Human Immunovirology and Computational Biology Group, Laboratory of Experimental & Computational Biology, Centre for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland 21702-1201, USA.
Nat Rev Microbiol. 2004 Feb;2(2):109-22. doi: 10.1038/nrmicro817.
Viruses have evolved to enter cells from all three domains of life--Bacteria, Archaea and Eukaryotes. Of more than 3,600 known viruses, hundreds can infect human cells and most of those are associated with disease. To gain access to the cell interior, animal viruses attach to host-cell receptors. Advances in our understanding of how viral entry proteins interact with their host-cell receptors and undergo conformational changes that lead to entry offer unprecedented opportunities for the development of novel therapeutics and vaccines.
病毒已经进化到能够从生命的所有三个领域——细菌、古菌和真核生物进入细胞。在已知的3600多种病毒中，数百种能够感染人类细胞，其中大多数与疾病有关。为了进入细胞内部，动物病毒会附着在宿主细胞受体上。我们对病毒进入蛋白如何与其宿主细胞受体相互作用以及如何经历导致进入的构象变化的理解取得了进展，这为开发新型治疗方法和疫苗提供了前所未有的机会。
