对普马拉病毒感染的免疫反应及流行性肾病的发病机制。
Immune responses to Puumala virus infection and the pathogenesis of nephropathia epidemica.
作者信息
Terajima Masanori, Vapalahti Olli, Van Epps Heather L, Vaheri Antti, Ennis Francis A
机构信息
Center for Infectious Disease and Vaccine Research, S5-326 University of Massachusetts Medical School, Worcester, 01655, USA.
出版信息
Microbes Infect. 2004 Feb;6(2):238-45. doi: 10.1016/j.micinf.2003.10.017.
PMID:15049335
Abstract
Puumala virus, causative agent of a mild form of hemorrhagic fever with renal syndrome, also known as nephropathia epidemica, induces long-lasting humoral and cellular immunity in patients. The virus itself is not cytopathic, and the immune responses to the virus may be involved in teh pathogenesis of the disease.
摘要
普马拉病毒是肾综合征出血热（又称流行性肾病）一种轻型形式的病原体，可在患者体内诱导产生持久的体液免疫和细胞免疫。该病毒本身无细胞病变效应，针对该病毒的免疫反应可能参与了疾病的发病机制。
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