Sukkar Samir G, Rossi Edoardo
Dietetics and Clinical Nutrition Unit, University-Hospital San Martino, Largo Rosanna Benzi 10, Genoa, Italy.
Autoimmun Rev. 2004 Mar;3(3):199-206. doi: 10.1016/j.autrev.2003.09.002.
The hypothesis that oxidative stress favours flogistic and immune processes inducing autoimmune rheumatic diseases (ARDs) and their complications is still under discussion. In this review we take into consideration both the aetiopathological role of the diet in such diseases and the possible efficacy of dietary supports as adjuvants for the usual specific therapies. Moreover, we shall examine the hypothetical pathophysiological role of oxidative stress on ARDs and their complications, the methods for its evaluation and the possibility of intervening on oxidative pathways by means of nutritional modulation. It is possible that in the future we will be able to control connective pathology by associating an immuno-modulating therapy ('re-educating') with natural products having an anti-oxidant activity to current immunosuppressive treatment (which has potentially toxic effects).
氧化应激促进炎症和免疫过程，进而引发自身免疫性风湿性疾病（ARDs）及其并发症这一假说仍在讨论中。在本综述中，我们既考虑了饮食在这类疾病中的病因病理作用，也考虑了饮食支持作为常规特异性疗法辅助手段的可能疗效。此外，我们将研究氧化应激在ARDs及其并发症中的假定病理生理作用、评估方法以及通过营养调节干预氧化途径的可能性。未来，通过将免疫调节疗法（“重新教育”）与具有抗氧化活性的天然产物相结合，有可能在当前具有潜在毒性作用的免疫抑制治疗基础上，控制结缔组织病变。
