Frost Floyd J, Muller Timothy B, Calderon Rebecca L, Craun Gunther F
Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA.
Ann Epidemiol. 2004 Aug;14(7):473-8. doi: 10.1016/j.annepidem.2003.06.002.
Sera from 1356 National Health and Nutrition Examination Survey (NHANES) III participants from seven primary sampling units were tested for serological responses to two Cryptosporidium antigen groups. Intensity of responses was compared by geographic area, age, sex, race/ethnicity, income, and hepatitis A seropositivity.
Cryptosporidium seropositivity for the 15/17-kDa and the 27-kDa antigen groups were defined by the intensity of the responses. Conditional and unconditional logistic regression was used to identify significant risk factors.
Hispanics, blacks, and females had a higher seropositivity. Younger participants and those with higher income had a lower seropositivity. Being hepatitis A seropositive was strongly related to a weak serological response to the 27-kDa antigen group. Family size was unrelated to Cryptosporidium seropositivity. Significantly higher Cryptosporidium seropositivity was observed for three of the seven primary sampling units.
This study found significant geographical differences in the occurrence and the intensity of serological response. Strong serological responses to the 15/17-kDa antigen occurred more commonly in blacks and Hispanics, individuals not having high incomes, and in older age groups.
对来自七个主要抽样单位的1356名国家健康和营养检查调查（NHANES）III参与者的血清进行检测，以了解其对两种隐孢子虫抗原组的血清学反应。通过地理区域、年龄、性别、种族/民族、收入和甲型肝炎血清阳性情况对反应强度进行比较。
根据反应强度确定15/17-kDa和27-kDa抗原组的隐孢子虫血清阳性情况。使用条件和无条件逻辑回归来确定显著的风险因素。
西班牙裔、黑人及女性的血清阳性率较高。较年轻的参与者和收入较高者的血清阳性率较低。甲型肝炎血清阳性与对27-kDa抗原组的血清学反应较弱密切相关。家庭规模与隐孢子虫血清阳性无关。在七个主要抽样单位中的三个单位观察到显著更高的隐孢子虫血清阳性率。
本研究发现血清学反应的发生率和强度存在显著的地理差异。对15/17-kDa抗原的强烈血清学反应在黑人、西班牙裔、低收入个体和老年人群中更为常见。
