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出血性异位静脉曲张——经颈静脉肝内门体分流术(TIPS)及栓塞治疗

Bleeding ectopic varices--treatment with transjugular intrahepatic porto-systemic shunt (TIPS) and embolisation.

作者信息

Vangeli Marcello, Patch David, Terreni Natalia, Tibballs John, Watkinson Anthony, Davies Neil, Burroughs Andrew Kenneth

机构信息

Liver Transplantation and Hepatobiliary Unit, Royal Free Hospital and NHS Hampstead Trust, London, UK.

出版信息

J Hepatol. 2004 Oct;41(4):560-6. doi: 10.1016/j.jhep.2004.06.024.

Abstract

BACKGROUND/AIMS: Bleeding ectopic varices due to cirrhosis can be difficult to manage. We report our experience of uncontrolled bleeding from ectopic varices treated with transjugular intrahepatic porto-systemic shunt (TIPS).

METHODS

We selected the 21 cirrhotics who underwent TIPS for bleeding ectopic varices from our database: Child-Pugh grade A (2), B (11) and C (8). Site of bleeding was rectal (11), colonic (2), ileal 1, jejunal 1, duodenal 1, and stomal (5).

RESULTS

TIPS was performed successfully in 19/21 (90%) patients. All except 1 had either a reduction in portosystemic pressure gradient < or = 12 mmHg (n=12) or reduction by 25-50% of baseline (n=6). TIPS alone was used in 12/19: 7 of these 12 had no further bleeding; 5 (42%) rebled within 48 h, and had embolisation, 4 without further bleeding. In 7 of 19, TIPS and embolisation were performed together: 2 patients (28%) rebled; further embolisation stopped the bleeding.

CONCLUSIONS

Ectopic varices do rebleed despite a reduction of porto-systemic pressure gradient < or = 12 mmHg or by 25-50% of baseline, following TIPS. Embolisation stopped bleeding in all but 1 patient. We recommend performing embolisation at the time of the initial TIPS to control bleeding from ectopic varices.

摘要

背景/目的:肝硬化引起的异位静脉曲张出血可能难以处理。我们报告经颈静脉肝内门体分流术(TIPS)治疗异位静脉曲张未控制出血的经验。

方法

我们从数据库中选取21例因异位静脉曲张出血接受TIPS治疗的肝硬化患者:Child-Pugh分级A级(2例)、B级(11例)和C级(8例)。出血部位为直肠(11例)、结肠(2例)、回肠1例、空肠1例、十二指肠1例和吻合口(5例)。

结果

19/21(90%)例患者TIPS操作成功。除1例患者外,所有患者的门体压力梯度均降低至≤12 mmHg(n = 12)或较基线降低25 - 50%(n = 6)。19例患者中12例仅接受了TIPS治疗:这12例中的7例未再出血;5例(42%)在48小时内再次出血,并接受了栓塞治疗,4例未再出血。19例中的7例同时进行了TIPS和栓塞治疗:2例患者(28%)再次出血;进一步栓塞止血。

结论

尽管TIPS后门体压力梯度降低至≤12 mmHg或较基线降低25 - 50%,异位静脉曲张仍会再次出血。除1例患者外,栓塞治疗止住了所有患者的出血。我们建议在初次TIPS时同时进行栓塞治疗以控制异位静脉曲张出血。

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