Chan A Y, Ho C S, Chan T Y, Swaminathan R
Department of Chemical Pathology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin.
Clin Chem. 1992 Mar;38(3):411-3.
We studied the changes in blood glucose concentration in blood samples collected in heparinized specimen tubes containing no other preservative, or containing NaF, D-mannose, or a combination of NaF and D-mannose. Blood concentration in samples taken into NaF decreased by 0.40 mmol/L in the first 2 h; thereafter, there was no change. In samples collected into mannose there was a small but significant decrease in blood glucose concentration with time. When samples containing mannose were analyzed immediately after collection, the concentration of glucose was higher than in later analyses, probably because of an exchange of intracellular glucose for extracellular mannose. When a combination of NaF and mannose was used, the blood glucose concentration was relatively stable but slightly higher than nonpreserved samples for the next 24 h. However, samples containing mannose were unsuitable for electrolyte analysis. We conclude that a combination of D-mannose and NaF may be a better preservative for blood glucose than either compound alone.
我们研究了在不含其他防腐剂、含有氟化钠（NaF）、D - 甘露糖或NaF与D - 甘露糖组合的肝素化标本管中采集的血样中血糖浓度的变化。采集到含NaF样本中的血样在最初2小时内血糖浓度下降了0.40 mmol/L；此后，没有变化。采集到含甘露糖样本中的血样，血糖浓度随时间有小幅但显著的下降。当含甘露糖的样本在采集后立即分析时，葡萄糖浓度高于随后的分析结果，这可能是由于细胞内葡萄糖与细胞外甘露糖发生了交换。当使用NaF和甘露糖的组合时，血糖浓度相对稳定，但在接下来的24小时内略高于未保存样本。然而，含甘露糖的样本不适合进行电解质分析。我们得出结论，D - 甘露糖和NaF的组合可能是比单独使用任何一种化合物更好的血糖防腐剂。
