Büchter A, Kleinheinz J, Wiesmann H-P, Seper L, Joos U, Meyer U
Klinik und Poliklinik für Mund- und Kiefer-Gesichtschirurgie, Universität Münster.
Mund Kiefer Gesichtschir. 2004 Sep;8(5):282-8. doi: 10.1007/s10006-004-0557-5. Epub 2004 Jul 23.
The treatment of patients with early or immediately loaded dental implants has renewed interest in the behavior of osseointegration at the implant surface. Whereas it is generally accepted that peri-implant tissue formation and mineralization are dependent on the local mechanical environment in the interface zone, controversies exist concerning the impact of implant design on peri-implant bone formation. The aim of the present study was the in vivo evaluation of peri-implant bone formation by two different implant systems: cylindrical (ITI) versus conical (ILI).
A total of 60 implants (30 ITI and 30 ILI) were placed in the cranial and caudal part of the tibia of eight Göttinger minipigs. Half of the minipigs were sacrificed at 7 days and 28 days of osseointegration. Implant-containing bone specimens were prepared for histological and ultrastructural investigations.
Histological and scanning electron-microscopic investigations showed a direct contact of bone-like minerals over the whole implant surface from day 7 of implant/bone interaction. Whereas the ILI implant showed direct contact up to the top of the crestal bone, ITI implants demonstrated a crestally located narrow gap without ossification over the whole experimental period.
Our investigations support the hypothesis of an implant design-inherent emergence and maintenance of crestal bone.
早期或即刻负重牙种植体患者的治疗重新引发了人们对种植体表面骨结合行为的关注。虽然一般认为种植体周围组织的形成和矿化依赖于界面区域的局部机械环境，但关于种植体设计对种植体周围骨形成的影响仍存在争议。本研究的目的是在体内评估两种不同种植体系统（圆柱形种植体[ITI]与锥形种植体[ILI]）周围的骨形成情况。
在8只哥廷根小型猪的胫骨颅侧和尾侧共植入60枚种植体（30枚ITI种植体和30枚ILI种植体）。在骨结合7天和28天时，将半数小型猪处死。制备含种植体的骨标本用于组织学和超微结构研究。
组织学和扫描电子显微镜研究显示，从种植体/骨相互作用的第7天起，在整个种植体表面均有类骨矿物质的直接接触。ILI种植体在整个实验期间直至嵴顶骨顶部均显示有直接接触，而ITI种植体在整个实验期间在嵴顶处显示有一个狭窄的无骨化间隙。
我们的研究支持种植体设计固有地影响嵴顶骨的形成和维持这一假说。
