来自药用层孔菌的新型羊毛甾烷型三萜类化合物。

New lanostane-type triterpenes from Fomes officinalis.

作者信息

Wu Xia, Yang JunShan, Zhou Liang, Dong YueSheng

机构信息

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100-094, People's Republic of China.

出版信息

Chem Pharm Bull (Tokyo). 2004 Nov;52(11):1375-7. doi: 10.1248/cpb.52.1375.

DOI:10.1248/cpb.52.1375

PMID:15516768

Abstract

Five new lanostane-type triterpenes, named fomefficinic acid A-E (1-5), were isolated from the dried sclerotium of Fomes officinalis, respectively. Their structures were established as 24-methylene-3-oxo-lanost-8-en-21-oic acid (1), 3alpha,15alpha-dihydroxy-24-methylene-lanosta-7,9(11)-dien-21-oic acid (2), 3alpha,15alpha-dihydroxy-24-methylene-lanost-8-en-21-oic acid (3), 15alpha-hydroxy-3-oxo-24-methylenelanost-8-en-21-oic acid (4), 15alpha-acetoxy-3-oxo-24-methylenelanosta-7,9(11)-dien-21-oic acid (5), by spectral analysis and chemical methods as well as comparison with known compounds.

摘要

从苦白蹄干燥菌核中分别分离得到5个新的羊毛甾烷型三萜，命名为苦白蹄酸A - E（1 - 5）。通过光谱分析、化学方法以及与已知化合物比较，确定它们的结构分别为24 - 亚甲基 - 3 - 氧代 - 羊毛甾 - 8 - 烯 - 21 - 酸（1）、3α,15α - 二羟基 - 24 - 亚甲基 - 羊毛甾 - 7,9(11) - 二烯 - 21 - 酸（2）、3α,15α - 二羟基 - 24 - 亚甲基 - 羊毛甾 - 8 - 烯 - 21 - 酸（3）、15α - 羟基 - 3 - 氧代 - 24 - 亚甲基羊毛甾 - 8 - 烯 - 21 - 酸（4）、15α - 乙酰氧基 - 3 - 氧代 - 24 - 亚甲基羊毛甾 - 7,9(11) - 二烯 - 21 - 酸（5）。