Grinfeld Esther, Kennedy Peter G E
Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Scotland, UK.
Virus Genes. 2004 Dec;29(3):317-9. doi: 10.1007/s11262-004-7434-z.
Immunohistochemical analysis of fixed tissue sections of human trigeminal ganglia (TG) and dorsal root ganglia (DRG) revealed the neuronal expression of proteins encoded by Varicella-zoster virus (VZV) genes 21, 29, 62 and 63. These proteins were detected mainly in the neuronal cytoplasm, are likely to be present in low abundance during VZV latency, and mirror the profile of VZV gene transcription.
对人类三叉神经节(TG)和背根神经节(DRG)固定组织切片进行的免疫组织化学分析显示,水痘-带状疱疹病毒(VZV)基因21、29、62和63编码的蛋白质在神经元中表达。这些蛋白质主要在神经元细胞质中被检测到,在VZV潜伏期间可能以低丰度存在,并且反映了VZV基因转录情况。