Sitas F, Urban M, Bradshaw D, Kielkowski D, Bah S, Peto R
National Health Laboratory Service, and Witwatersrand University, South Africa.
Tob Control. 2004 Dec;13(4):396-9. doi: 10.1136/tc.2004.007682.
In mid 1998, a question "Was the deceased a smoker five years ago?" was introduced on the newly revised South African death notification form.
A total of 16,230 new death notification forms from 1998 have been coded, and comparison of the prevalence of smoking among those who died of different causes was used to estimate, by case-control comparisons, tobacco attributed mortality in South Africa. Cases comprised deaths from causes known (from other studies) to be causally associated with smoking, and controls comprised deaths from medical conditions expected to be unrelated to smoking. Those who died from external causes, and from diseases strongly related to alcohol consumption, were excluded.
Reports were available from 5340 deceased adults (age 25+), whose smoking status was given by a family member.
Significantly increased risks were found for deaths from tuberculosis (odds ratio (OR) 1.61, 95% confidence interval (CI) 1.23 to 2.11), chronic obstructive pulmonary disease (COPD) (OR 2.5, 95% CI 1.9 to 3.4), lung cancer (OR 4.8, 95% CI 2.9 to 8.0), other upper aerodigestive cancer (OR 3.0, 95% CI 1.9 to 4.9) and ischaemic heart disease (OR 1.7, 95% CI 1.2 to 2.3).
If smokers had the same death rate as non-smokers, 58% of lung cancer deaths, 37% of COPD deaths, 20% of tuberculosis deaths, and 23% of vascular deaths would have been avoided. About 8% of all adult deaths in South Africa (more than 20 000 deaths a year) were caused by smoking.
1998年年中,新修订的南非死亡通知表格上增加了一个问题:“死者五年前吸烟吗?”
对1998年的16230份新死亡通知表格进行了编码,并通过病例对照比较,利用死于不同原因者的吸烟流行率比较,来估计南非烟草所致死亡率。病例包括死于(其他研究表明)与吸烟有因果关系的原因者,对照包括死于预计与吸烟无关的疾病者。死于外部原因以及与酒精消费密切相关疾病的人被排除在外。
有5340名成年死者(25岁及以上)的报告,其吸烟状况由家庭成员提供。
发现死于肺结核(优势比(OR)1.61,95%置信区间(CI)1.23至2.11)、慢性阻塞性肺疾病(COPD)(OR 2.5,95%CI 1.9至3.4)、肺癌(OR 4.8,95%CI 2.9至8.0)、其他上呼吸道消化道癌症(OR 3.0,95%CI 1.9至4.9)和缺血性心脏病(OR 1.7,95%CI 1.2至2.3)的风险显著增加。
如果吸烟者的死亡率与非吸烟者相同,那么58%的肺癌死亡、37%的慢性阻塞性肺疾病死亡、20%的肺结核死亡和23%的血管性死亡可以避免。南非约8%的成人死亡(每年超过20000例死亡)是由吸烟导致的。