Morikawa Y, Nakagawa H, Tabata M, Nishijo M, Senma M, Kitagawa Y, Kawano S, Teranishi H, Kido T
Department of Public Health, Kanazawa Medical University, Ishikawa.
Nihon Eiseigaku Zasshi. 1992 Feb;46(6):1057-62. doi: 10.1265/jjh.46.1057.
We studied an outbreak of itai-itai disease in the Jinzu River basin, in Toyama, Japan. One hundred and fifty females recognized as itai-itai disease patients till by 1990 were studied for the ages and years of onset and residence in the cadmium-polluted area. 1. Cases were recognized from as early as 1929, increased gradually to the peak of 1955-1959 and rapidly decreased up to the 1970s. 2. It was found that the later the patients was born, the younger the age of onset, though there was no difference of ages of onset between the cases born in the 1910s and the cases born from 1920. 3. The onset of itai-itai disease was most frequently seen at 50-59 years of residence in the cadmium-polluted area. It was found that the later a person started to inhabit the cadmium-polluted area, the shorter the period of residence in the cadmium-polluted area up to onset of itai-itai disease. 4. Comparing the patients who inhabited the cadmium-polluted area from birth and those who had moved there from non-polluted areas, the age of onset was higher in the latter, but there were no significant differences in the period of residence up to onset. From these findings, it appeared that itai-itai disease was not caused by aging, but by cadmium exposure starting from the 1910s.
我们对日本富山县神通川流域发生的痛痛病疫情进行了研究。截至1990年，共对150名被认定为痛痛病患者的女性进行了研究，分析她们的发病年龄、发病年份以及在镉污染地区的居住时间。1. 病例最早可追溯到1929年，随后逐渐增加，在1955 - 1959年达到峰值，到20世纪70年代迅速下降。2. 研究发现，患者出生时间越晚，发病年龄越小，不过出生于20世纪10年代的病例与出生于20世纪20年代的病例在发病年龄上并无差异。3. 痛痛病最常发生在居住在镉污染地区50 - 59年之后。研究发现，一个人开始居住在镉污染地区的时间越晚，直至患上痛痛病时在镉污染地区的居住时间就越短。4. 对比从出生就居住在镉污染地区的患者和从非污染地区迁移至此的患者，后者的发病年龄更高，但直至发病时的居住时间并无显著差异。从这些研究结果来看，痛痛病并非由衰老引起，而是始于20世纪10年代的镉暴露所致。
