Prasad Ratna Chakraborty, Herzog Birger, Boone Braden, Sims Lauren, Waltner-Law Mary
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
J Ethnopharmacol. 2005 Jan 4;96(1-2):295-301. doi: 10.1016/j.jep.2004.09.024.
Insulin action is impaired in diabetic patients, which leads to increased hepatic glucose production. Plants and herbs have been used for medicinal purposes, including the treatment of diabetes, for centuries. Since dietary management is a starting point for the treatment of diabetes, it is important to recognize the effect of plant-based compounds on tissues that regulate glucose metabolism, such as the liver. In a recent study, several herbs and spices were found to increase glucose uptake into adipocytes, an insulin-like effect. Our data reveal that Syzygium aromaticum (L.) Merrill and Perry (Myrtaceae) (commonly referred to as clove) extract acts like insulin in hepatocytes and hepatoma cells by reducing phosphoenolpyruvate carboxykinase (PEPCK) and glucose 6-phosphatase (G6Pase) gene expression. Much like insulin, clove-mediated repression is reversed by PI3K inhibitors and N-acetylcysteine (NAC). A more global analysis of gene expression by DNA microarray analysis reveals that clove and insulin regulate the expression of many of the same genes in a similar manner. These results demonstrate that consumption of certain plant-based diets may have beneficial effects for the treatment of diabetes and indicate a potential role for compounds derived from clove as insulin-mimetic agents.
糖尿病患者的胰岛素作用受损，这会导致肝脏葡萄糖生成增加。几个世纪以来，植物和草药一直被用于医学目的，包括治疗糖尿病。由于饮食管理是糖尿病治疗的起点，认识植物性化合物对调节葡萄糖代谢的组织（如肝脏）的影响很重要。在最近的一项研究中，发现几种草药和香料能增加脂肪细胞对葡萄糖的摄取，这是一种类似胰岛素的作用。我们的数据显示，丁香提取物在肝细胞和肝癌细胞中表现得像胰岛素，它通过降低磷酸烯醇式丙酮酸羧激酶（PEPCK）和葡萄糖6磷酸酶（G6Pase）的基因表达来实现。与胰岛素非常相似，丁香介导的抑制作用可被PI3K抑制剂和N-乙酰半胱氨酸（NAC）逆转。通过DNA微阵列分析对基因表达进行更全面的分析表明，丁香和胰岛素以相似的方式调节许多相同基因的表达。这些结果表明，食用某些植物性饮食可能对糖尿病治疗有有益作用，并表明丁香衍生的化合物作为胰岛素模拟剂具有潜在作用。
